Included below are two recent publications, in which researchers have used data from the 1000 Genomes Project to study psychiatric and neurological disorders.
In the first study, researchers used the 1000 Genomes Project data to study the impact of genetic variants on depression. Depression is a common mental health disorder influenced by inherited and environmental risk factors. The researchers compared how common and rare gene variation contributes to depression and they identified similarities in the genetic risk for depression and other psychiatric and neurodevelopmental conditions like autism and schizophrenia. This research helps to understand how gene changes influence depression and its connection to other mental health disorders.
In the second study, researchers used 1000 Genomes Project data to demonstrate the best way to perform and improve testing for genetic risk of MS in diverse populations. At present, the most established genetic risk factors for Multiple Sclerosis (MS) are located within the major histocompatibility complex (MHC), a crucial genetic region involved in immune response.
For more information:
Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression
Nature Communications, 2024 | https://doi.org/10.1038/s41467-024-45774-2
Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel
Human Immunology, 2024 | https://doi.org/10.1016/j.humimm.2024.110790
