The Personal Genome Project (PGP) is a long-term, large cohort study that aims to sequence and publicize the complete genomes and medical records of thousands of participants in order to enable personal genomics and personalized medicine research. The PGP is creating a freely available scientific resource placed within the public domain, bringing together genomic, environmental and human trait data so that researchers around the world can use it to understand how genes and environment influence each other, as well as to test various hypotheses about the relationships between genotype, environment and phenotype.
In collaboration with the PGP, the NIGMS Human Genetic Cell Repository (HGCR) offers cell lines and DNA samples from many PGP participants. PGP samples are highly characterized, including DNA sequencing data, self-reported medical information, environmental exposures and phenotypic traits. These samples have been consented for commercial use and for public posting of Personally Identifying Genetic Information (PIGI), which allows open-access, public posting of extensive genetic data. Examples of PIGI include whole-genome SNP array data, whole-exome sequences and whole-genome sequences.
Summary Details of NIGMS HGCR PGP Samples
| Categories | Sub-Categories | NIGMS HGCR PGP Samples |
|---|---|---|
| Sex | Male | 95 |
| Female | 40 | |
| Race | Asian, Other | 4 |
| Black | 1 | |
| White | 116 | |
| Chinese | 2 | |
| Hispanic/Latino | 3 | |
| More than 1 race | 4 | |
| Not reported | 5 | |
| Cell Type | B-Lymphocyte | 131 |
| Fibroblast | 4 | |
| Stem cell | 1 | |
| DNA | 19 |
The NIGMS HGCR offers over one hundred PGP samples of various cell types (B-lymphocytes, fibroblasts, iPSCs). PGP samples available include samples from multiple members of the same family and multiple cell types from the same individual.
NIGMS HGCR PGP Samples for Family Studies
| Catalog ID | Description | Cell Type | Gender | Age (Years) | Race | Family ID |
Relationship to Proband | Family Member |
|---|---|---|---|---|---|---|---|---|
| GM24385 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 45 | White | 3140 | Proband | 1 |
| GM24143 | PERSONAL GENOME PROJECT | B-Lymphocyte | Female | 74 | White | 3140 | Mother | 2 |
| GM24149 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 90 | White | 3140 | Father | 3 |
| GM24631 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 33 | Asian, Other | 3150 | Proband | 1 |
| GM24694 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 64 | Chinese | 3150 | Father | 2 |
| GM24695 | PERSONAL GENOME PROJECT | B-Lymphocyte | Female | 63 | Chinese | 3150 | Mother | 3 |
Multiple NIGMS HGCR PGP Samples from the Same Subject*
| Catalog ID | Description | Cell Type | Gender | Age at Collection | Race | Associated Specimens |
|---|---|---|---|---|---|---|
| GM20431 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 51 | White | 2980 |
| GM23248 | PERSONAL GENOME PROJECT | Fibroblast | Male | 55 | White | 2980 |
| GM23338 | APPARENTLY HEALTHY NON-FETAL TISSUE | Stem Cell | Male | 55 | White | 2980 |
| GM21677 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 42 | White | 2981 |
| GM23249 | PERSONAL GENOME PROJECT | Fibroblast | Male | 44 | White | 2981 |
| GM21687 | PERSONAL GENOME PROJECT | B-Lymphocyte | Male | 52 | White | 2982 |
| GM23250 | PERSONAL GENOME PROJECT | Fibroblast | Male | 44 | White | 2982 |
| GM21833 | PERSONAL GENOME PROJECT | B-Lymphocyte | Female | 46 | White | 2983 |
| GM23251 | PERSONAL GENOME PROJECT | Fibroblast | Female | 50 | White | 2983 |
*In response to requests from the scientific research community for multiple cell lines from a single individual, the NIGMS HGCR has assembled a number of collections of multiple cell lines. These cell lines and DNA samples can be found in the “Multiple Cell Lines From the Same Subject” collection. Please see additional information about this collection here.
All NIGMS HGCR PGP Samples Consented for Public Posting of PIGI
See NIGMS HGCR PGP Samples consented for public posting of PIGI here.
