Partners in Biomarker Research

A Biomarker is "a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to therapeutic intervention."

As genomic research into the causes and treatments of disease moves rapidly into the era of personalized medicine, an increasing number of biomedical studies are based on identifying "biomarkers" that will aid in the rapid and efficient prediction of susceptibility, diagnosis, prognosis and treatment of disease tailored to an individual.

Although the concept of biomarkers is a relatively recent development, Coriell Institute has been involved in the banking of valuable samples for biomarker studies since 2000. The Institute began storing plasma samples at ultra-low temperatures (-80 o C) for individual investigators, but now the collections number thousands of samples which are routinely distributed for biomarker studies.

Today, the range of samples stored at Coriell has expanded to include hundreds of thousands of biomarker specimens that include plasma, serum, urine, cerebrospinal fluid (CSF), RNA and DNA from fresh whole blood samples, and saliva.

Key Biomarker Research Services at Coriell

  • Receipt and storage of a variety of samples at optimal temperature including blood, plasma, serum, CSF, urine, saliva, blood DNA and RNA
  • Processing of samples to yield DNA, RNA, including rigorous Quality Control
  • Reporting of life-cycle of samples; enterprise level LIMS
  • Hemoglobin assays to assess quality of serum, plasma, and cerebrospinal fluid
  • Development of additional biomarker assays and QC
  • Redundant backup generators for all storage facilities
  • Controlled access to samples and associated data
  • Certified to the ISO9001:2008 standard

Role of Biomarkers in Medicine

Biomarkers are any measurable characteristics of an organism that reflect a particular physiological state. [ Learn More › ]

Characteristics of the Ideal Biomarker

An ideal biomarker may fill one of many different roles. It may be suitable for the early diagnosis of a disease, either as part of a routine screening exam or at the first sign of a questionable symptom. [ Learn More › ]


Challenges of Biomarker Research

Large-scale studies are currently underway on the discovery and validation of new and more effective biomarkers. [ Learn More › ]

Working with Coriell

Coriell is an expert in the field of biomarkers. [ Learn More › ]