NG11415
DNA from Fibroblast
Description:
ALZHEIMER DISEASE; AD
|
Repository
|
NIA Aging Cell Culture Repository
|
| Subcollection |
Alzheimer's Disease |
| Quantity |
10 µg |
| Quantitation Method |
Please see our FAQ |
|
Biopsy Source
|
Arm
|
|
Cell Type
|
Fibroblast
|
|
Tissue Type
|
Skin
|
|
Transformant
|
Untransformed
|
|
Sample Source
|
DNA from Fibroblast
|
|
Race
|
White
|
|
Ethnicity
|
FRENCH CANADIAN
|
|
Family Member
|
1
|
|
Relation to Proband
|
proband
|
|
Confirmation
|
Clinical summary/Case history
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| Passage Frozen |
10 |
| |
| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis |
| |
| Remarks |
Donor has a history of progressive dementia and memory loss with onset at age 48. Donor's deceased father and a sister were affected. Biopsy was taken ante-mortem from the upper arm. Culture was initiated on 11/19/90 using explants of minced skin tissue. The cell morphology is fibroblastlike. The karyotype is 46,XY with 4% of the cells examined showing random chromosome loss and 12% showing chromosomal rearrangements; normal diploid male. Culture was frozen at passage 4 and the PDL is unknown. A lymphoblast culture from same donor is AG11366. The legacy karyotype description shown in this Remark may not be representative of the current available product. |
| Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, et al, Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science258:668-71 1992 |
| PubMed ID: 1411576 |
|
|