NG06869
DNA from Fibroblast
Description:
ALZHEIMER DISEASE; AD
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Repository
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NIA Aging Cell Culture Repository
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| Subcollection |
Alzheimer's Disease
Alzheimer Disease With No Family History |
| Quantity |
10 µg |
| Quantitation Method |
Please see our FAQ |
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Biopsy Source
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Skin
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Cell Type
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Fibroblast
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Tissue Type
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Skin
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Transformant
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Untransformed
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Sample Source
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DNA from Fibroblast
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Race
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White
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Family Member
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1
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Relation to Proband
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proband
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| PDL at Freeze |
6.19 |
| Passage Frozen |
7 |
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Chromosome Analysis |
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| Remarks |
The donor had a history of moderate dementia, impaired memory, visuospacial disorientation, dyscalculia, a diffuse EEG and cortical atrophy on CAT scan. Negative family history for Alzheimer disease. Onset of the disease was at age 59 and was confirmed at autopsy. The culture was initiated on 5/19/83 using explants of minced skin tissue taken ante-mortem. The cell morphology is fibroblast-like and the karyotype is 46,XX; normal diploid female. A lymphoblast culture from same donor is AG06868A. The legacy karyotype description shown in this Remark may not be representative of the current available product. |
| Liu Z, Chao J, Wang C, Sun G, Roeth D, Liu W, Chen X, Li L, Tian E, Feng L, Davtyan H, Blurton-Jones M, Kalkum M, Shi Y, Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model Cell reports42:112841 2023 |
| PubMed ID: 37494190 |
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| Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y, Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure Advanced science (Weinheim, Baden-Wurttemberg, Germany)8:e2101462 2021 |
| PubMed ID: 34337898 |
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| Cui Q, Garcia G, Zhang M, Wang C, Li H, Zhou T, Sun G, Arumugaswami V, Shi Y, Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection iScience25:103684 2021 |
| PubMed ID: 34977495 |
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| Iannuzzi F, Frisardi V, Annunziato L, Matrone C, Might Fibroblasts from Patients with Alzheimer's Disease Reflect the Brain Pathology? A Focus on the Increased Phosphorylation of Amyloid Precursor Protein Tyr Brain sciences11:103684 2020 |
| PubMed ID: 33466666 |
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| Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA, REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease Cell reports26:1112-1127.e9 2018 |
| PubMed ID: 30699343 |
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| Parshad RP, Sanford KK, Price FM, Melnick LK, Nee LE, Schapiro MB, Tarone RE, Robbins JH, Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proc Natl Acad Sci U S A93:5146-50 1996 |
| PubMed ID: 8643543 |
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| Van Huynh T, Cole G, Katzman R, Huang KP, Saitoh T, Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. Arch Neurol46:1195-9 1989 |
| PubMed ID: 2684108 |
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