Coriell Institute
Repository NIA Aging Cell Culture Repository
Subcollection Italian Alzheimer Disease
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Race Caucasian
Ethnicity ITALIAN
Family Member 19
Relation to Proband V-1418
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The donor is an unaffected spouse of an Alzheimer's disease family member. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 11/16/84 using explants of minced skin. The cell morphology is fibroblast-like. Culture was frozen at PDL 9. A lymphoblast culture from same donor is AG07925.
PDL at Freeze 9
Passage Frozen 6
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis
 
Remark The donor is an unaffected spouse of an Alzheimer's disease family member. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 11/16/84 using explants of minced skin. The cell morphology is fibroblast-like. Culture was frozen at PDL 9. A lymphoblast culture from same donor is AG07925.
Qiang L, Fujita R, Yamashita T, Angulo S, Rhinn H, Rhee D, Doege C, Chau L, Aubry L, Vanti WB, Moreno H, Abeliovich A, Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons Cell146:359-71 2010
PubMed ID: 21816272
 
St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, et al, The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science235:885-90 1987
PubMed ID: 2880399
 
Foncin, Presenile Alzheimer's disease in a large kindred. Rev Neurol141:194 (1985):885-90 1985
PubMed ID: 4001707
No data is available
Cumulative PDL at Freeze 9
Passage Frozen 6
Split Ratio 1:3
Temperature 37 C
Percent CO2 5%
Medium Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids
Serum 15% fetal bovine serum Not inactivated
Substrate None specified
Subcultivation Method trypsin-EDTA

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