GM03671

GM03671 LCL from B-Lymphocyte

Description:

ACUTE LYMPHOCYTIC LEUKEMIA
LYMPHOSARCOMA

Affected:

Yes

Sex:

Female

Age:

3 YR (At Sampling)

Overview

Repository

NIGMS Human Genetic Cell Repository

Subcollection

Heritable Diseases

Class

Heritable Cancer Syndromes and other Cancers

Biopsy Source

Peripheral vein

Cell Type

T-Lymphocyte

Tissue Type

Blood

Transformant

Possibly Human T-cell Leukemia Virus

Sample Source

LCL from B-Lymphocyte

Race

White

Relation to Proband

proband

Confirmation

Clinical summary/Case history

ISCN

Species

Homo sapiens

Common Name

Human

Remarks

T cell line CCRF-CEM; virus particle free; positive for T cell 65,000 M.W. glycoprotein and negative for sIg and Ia (B cell) antigen; all cells show 8p-, -18, inv(X), and +20; 6% of cells are diploid, 94% tetraploid; all show random chromosome abnormalities

Characterizations

IDENTIFICATION OF SPECIES OF ORIGIN

Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis

Phenotypic Data

Remarks

Publications

Goldman F, Bouarich R, Kulkarni S, Freeman S, Du HY, Harrington L, Mason PJ, Londoño-Vallejo A, Bessler M, The effect of TERC haploinsufficiency on the inheritance of telomere length Proceedings of the National Academy of Sciences of the United States of America102:17119-24 2005

PubMed ID: 16284252

Knudson M, Kulkarni S, Ballas Z, Bessler M, Goldman F, Association of Immune Abnormalities with Telomere Shortening in Autosomal Dominant Dyskeratosis Congenita. BloodEpub ahead of print:17119-24 2004

PubMed ID: 15238429

Lattier DL, States JC, Hutton JJ, Wiginton DA, Cell type-specific transcriptional regulation of the human adenosine deaminase gene. Nucleic Acids Res17:1061-76 1989

PubMed ID: 2784203

Wellner VP, Anderson ME, Puri RN, Jensen GL, Meister A, Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc Natl Acad Sci U S A81:4732-5 1984

PubMed ID: 6146978

Dalla-Favera R, Franchini G, Martinotti S, Wong-Staal F, Gallo RC, Croce CM, Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci U S A79:4714-7 1982

PubMed ID: 6289315

Daddona PE, Human adenosine deaminase. Properties and turnover in cultured T and B lymphoblasts. J Biol Chem256:12496-501 1981

PubMed ID: 6975278

Latt SA, Barell EF, Dougherty CP, Lazarus H, Patterns of late replication in X chromosomes of human lymphoid cells. Cancer Genet Cytogenet3:171-81 1981

PubMed ID: 6974041

Omary MB, Trowbridge IS, Covalent binding of fatty acid to the transferrin receptor in cultured human cells. J Biol Chem256:4715-8 1981

PubMed ID: 6262300

Pollack MS, Heagney SD, Livingston PO, Fogh J, HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines. J Natl Cancer Inst66:1003-12 1981

PubMed ID: 7017212

Ralston MD, DeMartino JL, Howe RC, Humphreys RE, Identification of external membrane proteins of the T lymphoblast cell line CCRF-CEM. Exp Cell Res123:237-45 1979

PubMed ID: 315324

Carrel S, Gross N, Salvi S, Rabbit antiserum against Daudi-cell membrane fractions detects cell surface antigens present on subpopulations of human lymphocytes. J Immunol120:1587-93 1978

PubMed ID: 307019

Kaplan J, Shope TC, Peterson WD Jr, Epstein-barr virus-negative human malignant T-cell lines. J Exp Med139:1070-6 1974

PubMed ID: 4363409

Royston I, Graze PR, Pitts RB, Failure of cultured human T-cell lymphoid lines to stimulate in mixed leukocyte culture. J Natl Cancer Inst53:361-7 1974

PubMed ID: 4276467

Krishan A, Raychaudhuri R, Flowers A, Karyotype studies on human leukemic lymphoblasts in vitro and as serial transplants in neonatal syrian hamsters. J Natl Cancer Inst43:1203-14 1969

PubMed ID: 5273072

Adams RA, Foley GE, Uzman BG, Farber S, Lazarus S, Kleinman L, Leukemia: serial transplantation of human leukemic lymphoblasts in the newborn Syrian hamster. Cancer Res27:772-83 1967

PubMed ID: 4295047

Uzman BG, Foley GE, Farber S, Lazarus H, Morphologic variations in human leukemic lymphoblasts (CCRF-CEM cells) after long-term culture and exposure to chemotherapeutic agents. A study with the electron microscope. Cancer19:1725-42 1966

PubMed ID: 5224274

Foley, Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia. Cancer18:522 (1965):1725-42 1965

PubMed ID: 5224274

McCarthy RE, Junius V, Farber S, Lazarus H, Foley GE, Cytogenetic analysis of human lymphoblasts in continuous culture. Exp Cell Res40:197-200 1965

PubMed ID: 5320250