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NA23687 DNA from LCL

Description:

SPINAL MUSCULAR ATROPHY I; SMA1

Affected:

No

Sex:

Female

Age:

No Data

  • Overview
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Heritable Diseases
Quantity 25 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Race White
Ethnicity Hispanic/Latino
Ethnicity Mexican/Guatemalan
Family Member 2
Family History N
Relation to Proband mother
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks Clinically unaffected mother of an affected child (GM23686); NGS, and MLPA analysis revealed that donor subject has 1 copy of the SMN1 gene and 2 copies of the SMN2 gene; unaffected father of affected child is GM23688.

Phenotypic Data

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Remarks Clinically unaffected mother of an affected child (GM23686); NGS, and MLPA analysis revealed that donor subject has 1 copy of the SMN1 gene and 2 copies of the SMN2 gene; unaffected father of affected child is GM23688.

Publications

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Prior TW, Bayrak-Toydemir P, Lynnes TC, Mao R, Metcalf JD, Muralidharan K, Iwata-Otsubo A, Pham HT, Pratt VM, Qureshi S, Requesens D, Shen J, Vetrini F, Kalman L, Characterization of Reference Materials for Spinal Muscular Atrophy Genetic Testing: A Genetic Testing Reference Materials Coordination Program Collaborative Project The Journal of molecular diagnostics : JMD23:103-110 2021
PubMed ID: 33197628
 
Jiang L, Lin R, Gallagher S, Zayac A, Butchbach MER, Hung P, Development and validation of a 4-color multiplexing spinal muscular atrophy (SMA) genotyping assay on a novel integrated digital PCR instrument Scientific reports10:19892 2020
PubMed ID: 33199817
 
Azad AK, Huang CK, Jin H, Zou H, Yanakakis L, Du J, Fiddler M, Naeem R, Goldstein Y, Enhanced Carrier Screening for Spinal Muscular Atrophy: Detection of Silent (SMN1: 2 + 0) Carriers Utilizing a Novel TaqMan Genotyping Method Laboratory medicine10:19892 2019
PubMed ID: 31875889
 
Stabley DL, Holbrook J, Harris AW, Swoboda KJ, Crawford TO, Sol-Church K, Butchbach MER, Establishing a reference dataset for the authentication of spinal muscular atrophy cell lines using STR profiling and digital PCR Neuromuscular disorders : NMD27:439-446 2016
PubMed ID: 28284873
 
Stabley DL, Harris AW, Holbrook J, Chubbs NJ, Lozo KW, Crawford TO, Swoboda KJ, Funanage VL, Wang W, Mackenzie W, Scavina M, Sol-Church K, Butchbach ME, SMN1 and SMN2 copy numbers in cell lines derived from patients with spinal muscular atrophy as measured by array digital PCR Molecular genetics & genomic medicine3:248-57 2015
PubMed ID: 26247043

External Links

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NCBI GTR 253300 SPINAL MUSCULAR ATROPHY, TYPE I; SMA1
OMIM 253300 SPINAL MUSCULAR ATROPHY, TYPE I; SMA1
Omim Description MUSCULAR ATROPHY, INFANTILE
  SMA I
  SMA, INFANTILE ACUTE FORM
  SPINAL MUSCULAR ATROPHY I; SMA1
  WERDNIG-HOFFMANN DISEASE
Pricing
International/Commercial/For-profit:
$281.00USD
U.S. Academic/Non-profit/Government:
$139.00USD
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