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NA04680 DNA from LCL

Description:

LEUKEMIA, CHRONIC MYELOID; CML

Affected:

Yes

Sex:

Female

Age:

No Data

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Heritable Diseases
Class Heritable Cancer Syndromes and other Cancers
Quantity 25 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Relation to Proband proband
Confirmation Clinical summary/Case history
ISCN 92,XXXX[25]/46,XX[50]
Species Homo sapiens
Common Name Human
Remarks Line IM9; G6PD type B; possesses surface receptors for human growth hormone, insulin, and calcitonin; synthesizes IgG; negative for reverse transcriptase; 60% 46,XX/40% 92,XXXX with random chromosome loss/gain

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase Isoenzyme Electrophoresis and by Chromosome Analysis
 

Phenotypic Data

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Remarks Line IM9; G6PD type B; possesses surface receptors for human growth hormone, insulin, and calcitonin; synthesizes IgG; negative for reverse transcriptase; 60% 46,XX/40% 92,XXXX with random chromosome loss/gain

Publications

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Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A, Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation Human molecular genetics: 2021
PubMed ID: 35394024
 
Martins IJ, Hone E, Chi C, Seydel U, Martins RN, Redgrave TG, Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice. J Lipid Res41:205-13 2000
PubMed ID: 10681404
 
Fantus IG, Saviolakis GA, Hedo JA, Gorden P, Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes. J Biol Chem257:8277-83 1982
PubMed ID: 7045118
 
Iwamoto Y, Maddux B, Goldfine ID, Chloroquine stimulation of insulin binding to IM-9 lymphocytes: evidence for action at a nonlysosomal site. Biochem Biophys Res Commun103:863-71 1981
PubMed ID: 7036998
 
Van Obberghen E, De Meyts P, Roth J, Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers. J Biol Chem251:6844-51 1976
PubMed ID: 185222
 
Gavin JR 3d, Roth J, Neville DM Jr, Meyts P de, Buell DN, Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A71:84-8 1974
PubMed ID: 4359334
 
Lesniak MA, Gorden P, Roth J, Gavin JR 3d, Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay. J Biol Chem249:1661-7 1974
PubMed ID: 4361817
 
Fahey JL, Buell DN, Sox HC, Proliferation and differentiation of lymphoid cells: studies with human lymphoid cell lines and immunoglobulin synthesis. Ann N Y Acad Sci190:221-34 1972
PubMed ID: 5290016

External Links

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dbSNP dbSNP ID: 21341
NCBI GTR 608232 LEUKEMIA, CHRONIC MYELOID; CML
OMIM 608232 LEUKEMIA, CHRONIC MYELOID; CML
Omim Description LEUKEMIA CHRONIC MYELOID; CML
Pricing
International/Commercial/For-profit:
$281.00USD
U.S. Academic/Non-profit/Government:
$139.00USD
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  • GM04680 - B-Lymphocyte
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