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NA03161 DNA from LCL

Description:

HLA HISTOCOMPATIBILITY TYPE: 142800 THROUGH 142860 & 142880

Affected:

No Data

Sex:

Female

Age:

No Data

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NIGMS Human Genetic Cell Repository
Subcollection Heritable Diseases
Quantity 25 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Relation to Proband proband
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks HLA type; A:3,3,B:7,7,D:2,2,DR:2,2 line MST1

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis
 
GENE MAPPING & DOSAGE STUDIES - Y CHROMOSOME PCR analysis of DNA from this cell culture gave a negative result with a primer for Yq11, DYS227.
 
HLA TYPING HLA type; A:3,3; B:7,7; D:2,2; DR:2,2
 

Phenotypic Data

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Remarks HLA type; A:3,3,B:7,7,D:2,2,DR:2,2 line MST1

Publications

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Jameson J, Cruz J, Ennis FA, Human cytotoxic T-lymphocyte repertoire to influenza A viruses. J Virol72(11):8682-9 1998
PubMed ID: 9765409
 
Mathew A, Kurane I, Green S, Stephens HA, Vaughn DW, Kalayanarooj S, Suntayakorn S, Chandanayingyong D, Ennis FA, Rothman AL, Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection. J Virol72(5):3999-4004 1998
PubMed ID: 9557687
 
Woulfe SL, Bono CP, Zacheis ML, Welply JK, Kirschmann DA, Baudino TA, Wang Y, Stone DA, Hanson GJ, Vuletich JL, Bedell LJ, Schwartz BD, Howard SC, A peptidomimetic that specifically inhibits human leukocyte antigen DRB1*0401-restricted T cell proliferation. J Pharmacol Exp Ther281:663-9 1997
PubMed ID: 9152371
 
Woulfe SL, Bono CP, Zacheis ML, Kirschmann DA, Baudino TA, Swearingen C, Karr RW, Schwartz BD, Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401. Arthritis Rheum38:1744-53 1995
PubMed ID: 8849346
 
Roudier J, Petersen J, Rhodes GH, Luka J, Carson DA, Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. Proc Natl Acad Sci U S A86:5104-8 1989
PubMed ID: 2472638
 
Cole JL, Housley GA Jr, Dykman TR, MacDermott RP, Atkinson JP, Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines. Proc Natl Acad Sci U S A82:859-63 1985
PubMed ID: 3871945
 
Giles RC, DeMars R, Chang CC, Capra JD, Allelic polymorphism and transassociation of molecules encoded by the HLA-DQ subregion. Proc Natl Acad Sci U S A82:1776-80 1985
PubMed ID: 3856859
 
Walker LE, Ketler TA, Houghten RA, Schulz G, Chersi A, Reisfeld RA, Human major histocompatibility complex class I antigens: residues 61-83 of the HLA-B7 heavy chain specify an alloreactive site. Proc Natl Acad Sci U S A82:539-42 1985
PubMed ID: 3881768
 
Brodsky FM, A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics19:179-194 1984
PubMed ID: 6200433
 
Engelhard VH, Benjamin C, Xenogeneic cytotoxic T-cell clones recognize alloantigenic determinants on HLA-A2. Immunogenetics18:461-473 1983
PubMed ID: 6196283
 
Shipp MA, Schwartz BD, Kannapell CC, Griffith RC, Scott MG, Ahmed P, Davie JM, Nahm MH, A unique DR-related B cell differentiation antigen. J Immunol131:2458-67 1983
PubMed ID: 6415171
 
Finn OJ, Levy R, Multiple HLA-DR antigens: detection with monoclonal antibodies and translation in vitro. Proc Natl Acad Sci U S A79:2658-62 1982
PubMed ID: 6979750
 
Karr RW, Kannapell CC, Stein JA, Fuller TC, Duquesnoy RJ, Rodey GE, Mann DL, Gebel HM, Schwartz BD, Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis. J Exp Med156:652-7 1982
PubMed ID: 6980260
 
Quaranta V, Walker LE, Ruberto G, Pellegrino MA, Ferrone S, The free and the beta 2-microglobulin-associated heavy chains of HLA-A, B alloantigens share the antigenic determinant recognized by the monoclonal antibody Q1/28. Immunogenetics13:285-95 1981
PubMed ID: 6168579

External Links

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dbSNP dbSNP ID: 10612
Gene Cards HLA-A
HLA-DPA1
HLA-DRA
Gene Ontology GO:0005887 integral to plasma membrane
GO:0006955 immune response
GO:0019883 antigen presentation, endogenous antigen
GO:0019884 antigen presentation, exogenous antigen
GO:0019885 antigen processing, endogenous antigen via MHC class I
GO:0019886 antigen processing, exogenous antigen via MHC class II
GO:0030106 MHC class I receptor activity
GO:0045012 MHC class II receptor activity
NCBI Gene Gene ID:3105
Gene ID:3113
Gene ID:3122
NCBI GTR 142800 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A
142860 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR ALPHA; HLA-DRA
142880 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1; HLA-DPA1
OMIM 142800 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A
142860 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR ALPHA; HLA-DRA
142880 MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1; HLA-DPA1
Omim Description HLA-A HISTOCOMPATIBILITY TYPE
  MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A
  HLA-DR HISTOCOMPATIBILITY TYPE; HLA-DRA
  MAJOR HISTOCOMPATIBILITY COMPLEX II, DR ALPHA; HLA-DRA1
  HLA-SB HISTOCOMPATIBILITY TYPE; HLASB; HLADP
  MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DP ALPHA-1; HLA-DPA1
Pricing
International/Commercial/For-profit:
$281.00USD
U.S. Academic/Non-profit/Government:
$139.00USD
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