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NG20623 DNA from LCL

Description:

NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM

Affected:

No

Sex:

Female

Age:

92 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Apparently Healthy Collection
Quantity 10 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Race White
Relation to Proband proband
Confirmation Clinical summary/Case history
ISCN 47,XX,+12[25]/46,XX,t(2;7)(2qter>2p13::7q22>7qter;7pter>7q22::2p13>2pter)[4]/46,XX[21]
Species Homo sapiens
Common Name Human
Remarks Donor reports anemia, gall stones, hysterectomy, slight hearing loss with aids in both ears, cataracts removed by surgery, hand tremor, and memory loss (atributed by husband to diagnosed early stage Alzheimer disease); family history of hypertension (mother); never smoked; a sister is 90 years of age

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin confirmed by LINE assay
 

Phenotypic Data

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Demographic Data
Relation to Proband proband
Age at Sampling 92 YR
Sex Female
Age of Onset(If not a control) No Data
Age at Diagnosis(If not a control) No Data
Hispanic or Latino/Not Hispanic or Latino not yet reported
Racial Category White
Country No Data
Diagnosed By No Data
 
Data Elements
Clinical Element Type: Longevity
  (Baseline)
Heart Disease
High blood pressure Yes  No   Unknown  Not applicable 
Coronary artery disease Yes  No   Unknown  Not applicable 
Heart attack Yes  No   Unknown  Not applicable 
Valvular disease Yes  No   Unknown  Not applicable 
Atherosclerosis Yes  No   Unknown  Not applicable 
Other  No Data
Blood Disorders
Anemia Yes   No  Unknown  Not applicable 
Polycythemia Yes  No   Unknown  Not applicable 
Multiple myeloma Yes  No   Unknown  Not applicable 
Other  No Data
Lung Disease
Emphysema Yes  No   Unknown  Not applicable 
Asthma Yes  No   Unknown  Not applicable 
Shortness of breath Yes  No   Unknown  Not applicable 
Other  No Data
Gastrointestinal
Gastroesophageal reflux disease Yes  No   Unknown  Not applicable 
Gastritis Yes  No   Unknown  Not applicable 
Ulcers Yes  No   Unknown  Not applicable 
Polyps Yes  No   Unknown  Not applicable 
Other  No Data
Genitourinary
Benign prostate hypertrophy Yes  No   Unknown  Not applicable 
Cysts Yes  No   Unknown  Not applicable 
Hysterectomy Yes   No  Unknown  Not applicable 
Kidney/bladder stones Yes  No   Unknown  Not applicable 
Urinary frequency Yes  No   Unknown  Not applicable 
Other  GALL STONES
Joint Diseases
Osteoarthritis Yes   No  Unknown  Not applicable 
Rheumatoid arthritis Yes  No   Unknown  Not applicable 
Osteoporosis Yes  No   Unknown  Not applicable 
Degenerative joint disease Yes  No   Unknown  Not applicable 
Other  No Data
Neurological & Psychiatric Disorders
Alzheimer disease Yes   No  Unknown  Not applicable 
Depression Yes  No   Unknown  Not applicable 
Anxiety Yes  No   Unknown  Not applicable 
Parkinson Disease Yes  No   Unknown  Not applicable 
Stroke Yes  No   Unknown  Not applicable 
Memory loss Yes   No  Unknown  Not applicable 
Hearing loss Yes  No   Unknown  Not applicable 
Insomnia Yes  No   Unknown  Not applicable 
Other  No Data
Eye Diseases
Cataracts Yes   No  Unknown  Not applicable 
Glaucoma Yes  No   Unknown  Not applicable 
Macular degeneration Yes  No   Unknown  Not applicable 
Other  No Data
General Health/Lifestyle
Diabetes Yes  No   Unknown  Not applicable 
If yes, then type:   Not applicable
Frailty Yes  No   Unknown  Not applicable 
High cholesterol Yes  No   Unknown  Not applicable 
Overweight Yes  No   Unknown  Not applicable 
Severe weight loss Yes  No   Unknown  Not applicable 
Smoker Yes  No   Unknown  Not applicable 
# of years as a smoker  0
Alcohol use Yes   No  Unknown  Not applicable 
Frequency of alcohol use   Less often
Cancer Yes  No   Unknown  Not applicable 
If yes, then type:  No Data
Family History
Relative(s) over 90 years old Yes   No  Unknown  Not applicable 
Arthritis Yes  No   Unknown  Not applicable 
Diabetes Yes  No   Unknown  Not applicable 
Heart disease Yes  No   Unknown  Not applicable 
Hypertension Yes   No  Unknown  Not applicable 
High cholesterol Yes  No   Unknown  Not applicable 
Obesity Yes  No   Unknown  Not applicable 
Cancer Yes  No   Unknown  Not applicable 
If yes, then type:  No Data
Alzheimer disease Yes  No   Unknown  Not applicable 
Macular degeneration Yes  No   Unknown  Not applicable 
Other (including familial genetic disease)  No Data
Remarks Donor reports anemia, gall stones, hysterectomy, slight hearing loss with aids in both ears, cataracts removed by surgery, hand tremor, and memory loss (atributed by husband to diagnosed early stage Alzheimer disease); family history of hypertension (mother); never smoked; a sister is 90 years of age

Publications

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Bracci AN, Dallmann A, Ding Q, Hubisz MJ, Caballero M, Koren A, The evolution of the human DNA replication timing program Proceedings of the National Academy of Sciences of the United States of America120:e2213896120 2023
PubMed ID: 36848554
 
Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A, Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation Human molecular genetics120:e2213896120 2021
PubMed ID: 35394024
Pricing
Commercial:
$155.00USD
Academic &
Non-profit:
$72.00USD
NIA Grantees:
$62.00USD
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