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NG20429 DNA from LCL

Description:

NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM

Affected:

No

Sex:

Male

Age:

91 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Apparently Healthy Collection
Quantity 10 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Race White
Ethnicity ENGLISH/WELSH/GERMAN
Family Member 1
Relation to Proband proband
Confirmation Clinical summary/Case history
ISCN 46,XY
Species Homo sapiens
Common Name Human
Remarks Donor reports influenza in 1918 at age 4, bladder cancer at age 72 and 74 yr, heart attack, coronary artery disease diagnosed at age 42 yr, colon polyps resected at age 80 yr, left hyrocele at age 91 yr, osteoarthritis, cataracts removed at age 81 yr, glaucoma, retinal eschemia at 88, hearing loss, peripheral neuropathy, smoked one pack a day for 20 years, and had appendectomy at age 12 yr; family history of diabetes (brother) and heart disease (father); mother lived to be 97 years of age; a second lymphoblast cell line taken 5 years earlier from this same donor is AG16730

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin confirmed by LINE assay
 

Phenotypic Data

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Demographic Data
Relation to Proband proband
Age at Sampling 91 YR
Sex Male
Age of Onset(If not a control) No Data
Age at Diagnosis(If not a control) No Data
Hispanic or Latino/Not Hispanic or Latino not yet reported
Racial Category White
Country No Data
Diagnosed By No Data
 
Data Elements
Clinical Element Type: Longevity
  (Baseline)
Heart Disease
High blood pressure Yes  No   Unknown  Not applicable 
Coronary artery disease Yes   No  Unknown  Not applicable 
Heart attack Yes   No  Unknown  Not applicable 
Valvular disease Yes  No   Unknown  Not applicable 
Atherosclerosis Yes  No   Unknown  Not applicable 
Other  No Data
Blood Disorders
Anemia Yes  No   Unknown  Not applicable 
Polycythemia Yes  No   Unknown  Not applicable 
Multiple myeloma Yes  No   Unknown  Not applicable 
Other  SEPTICEMIA
Lung Disease
Emphysema Yes  No   Unknown  Not applicable 
Asthma Yes  No   Unknown  Not applicable 
Shortness of breath Yes  No   Unknown  Not applicable 
Other  No Data
Gastrointestinal
Gastroesophageal reflux disease Yes  No   Unknown  Not applicable 
Gastritis Yes  No   Unknown  Not applicable 
Ulcers Yes  No   Unknown  Not applicable 
Polyps Yes   No  Unknown  Not applicable 
Other  No Data
Genitourinary
Benign prostate hypertrophy Yes  No   Unknown  Not applicable 
Cysts Yes  No   Unknown  Not applicable 
Hysterectomy Yes  No   Unknown  Not applicable 
Kidney/bladder stones Yes  No   Unknown  Not applicable 
Urinary frequency Yes  No   Unknown  Not applicable 
Other  HYDROCELE
Joint Diseases
Osteoarthritis Yes   No  Unknown  Not applicable 
Rheumatoid arthritis Yes  No   Unknown  Not applicable 
Osteoporosis Yes  No   Unknown  Not applicable 
Degenerative joint disease Yes  No   Unknown  Not applicable 
Other  No Data
Neurological & Psychiatric Disorders
Alzheimer disease Yes  No   Unknown  Not applicable 
Depression Yes  No   Unknown  Not applicable 
Anxiety Yes  No   Unknown  Not applicable 
Parkinson Disease Yes  No   Unknown  Not applicable 
Stroke Yes  No   Unknown  Not applicable 
Memory loss Yes  No   Unknown  Not applicable 
Hearing loss Yes   No  Unknown  Not applicable 
Insomnia Yes  No   Unknown  Not applicable 
Other  PERIPHERAL NEUROPATHY
Eye Diseases
Cataracts Yes   No  Unknown  Not applicable 
Glaucoma Yes   No  Unknown  Not applicable 
Macular degeneration Yes  No   Unknown  Not applicable 
Other  RETINAL ISCHEMIA
General Health/Lifestyle
Diabetes Yes  No   Unknown  Not applicable 
If yes, then type:   Not applicable
Frailty Yes  No   Unknown  Not applicable 
High cholesterol Yes  No   Unknown  Not applicable 
Overweight Yes  No   Unknown  Not applicable 
Severe weight loss Yes  No   Unknown  Not applicable 
Smoker Yes   No  Unknown  Not applicable 
# of years as a smoker  20
Alcohol use Yes   No  Unknown  Not applicable 
Frequency of alcohol use  Daily
Cancer Yes   No  Unknown  Not applicable 
If yes, then type:  BLADDER
Family History
Relative(s) over 90 years old Yes   No  Unknown  Not applicable 
Arthritis Yes  No   Unknown  Not applicable 
Diabetes Yes   No  Unknown  Not applicable 
Heart disease Yes   No  Unknown  Not applicable 
Hypertension Yes  No   Unknown  Not applicable 
High cholesterol Yes  No   Unknown  Not applicable 
Obesity Yes  No   Unknown  Not applicable 
Cancer Yes  No   Unknown  Not applicable 
If yes, then type:  No Data
Alzheimer disease Yes  No   Unknown  Not applicable 
Macular degeneration Yes  No   Unknown  Not applicable 
Other (including familial genetic disease)  No Data
Remarks Donor reports influenza in 1918 at age 4, bladder cancer at age 72 and 74 yr, heart attack, coronary artery disease diagnosed at age 42 yr, colon polyps resected at age 80 yr, left hyrocele at age 91 yr, osteoarthritis, cataracts removed at age 81 yr, glaucoma, retinal eschemia at 88, hearing loss, peripheral neuropathy, smoked one pack a day for 20 years, and had appendectomy at age 12 yr; family history of diabetes (brother) and heart disease (father); mother lived to be 97 years of age; a second lymphoblast cell line taken 5 years earlier from this same donor is AG16730

Publications

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Bracci AN, Dallmann A, Ding Q, Hubisz MJ, Caballero M, Koren A, The evolution of the human DNA replication timing program Proceedings of the National Academy of Sciences of the United States of America120:e2213896120 2023
PubMed ID: 36848554
 
Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A, Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation Human molecular genetics120:e2213896120 2021
PubMed ID: 35394024
Pricing
Commercial:
$155.00USD
Academic &
Non-profit:
$72.00USD
NIA Grantees:
$62.00USD
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