I90-10
Fibroblast from Lung, Lung
Description:
IMR-90 - NORMAL HUMAN FETAL LUNG FIBROBLAST
|
Repository
|
NIA Aging Cell Culture Repository
|
| Subcollection |
IMR90/IMR91 Cell Cultures
Specially Characterized Fibroblasts |
|
Biopsy Source
|
Lung
|
|
Cell Type
|
Fibroblast
|
|
Tissue Type
|
Lung
|
|
Transformant
|
Untransformed
|
|
Sample Source
|
Fibroblast from Lung, Lung
|
|
Race
|
White
|
|
Relation to Proband
|
proband
|
|
Confirmation
|
Clinical summary/Case history
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| PDL at Senescence |
62 |
| PDL at Freeze |
19 |
| Passage Frozen |
5 |
| |
| Remarks |
The IMR-90 line was established on 7/7/75 using explants of minced lung tissue obtained from a clinically normal 16 week fetus. The karyotype is 46,XX; normal diploid female. No variant isoenzyme patterns found for lactate dehydrogenase, malate dehydrogenase, 6-phosphogluconate dehydrogenase, and glucose-6-phosphate dehydrogenase; G6PD is isoenzyme type B. The HLA type is A2, B12, BW40, B5. Reverse transcriptase was not detected. The maximum number of population doublings achieved to senescence range from 58-73. Earlier passage IMR-90 cells available only with permission of NIA: see guidelines in Science 196:60-63 (1977). The legacy karyotype description shown in this Remark may not be representative of the current available product. |
| Lussier-Price M, Wahba HM, Mascle XH, Cappadocia L, Bourdeau V, Gagnon C, Igelmann S, Sakaguchi K, Ferbeyre G, Omichinski JG, Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1 Nucleic acids research: 2022 |
| PubMed ID: 35871297 |
| |
| Del Toro N, Lessard F, Bouchard J, Mobasheri N, Guillon J, Igelmann S, Tardif S, Buffard T, Bourdeau V, Brakier-Gingras L, Ferbeyre G, Cellular Senescence limits Translational Readthrough Biology open: 2021 |
| PubMed ID: 34676390 |
| |
| Barnes JW, Duncan D, Helton S, Hutcheson S, Kurundkar D, Logsdon NJ, Locy M, Garth J, Denson R, Farver C, Vo HT, King G, Kentrup D, Faul C, Kulkarni T, De Andrade JA, Yu Z, Matalon S, Thannickal VJ, Krick S, Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis American journal of physiology Lung cellular and molecular physiology317:L141-L154 2020 |
| PubMed ID: 31042083 |
| |
| Locy ML, Rangarajan S, Yang S, Johnson MR, Bernard K, Kurundkar A, Bone NB, Zmijewski JW, Byun J, Pennathur S, Zhou Y, Thannickal VJ, Oxidative cross-linking of fibronectin confers protease resistance and inhibits cellular migration Science signaling13:L141-L154 2020 |
| PubMed ID: 32788339 |
| |
| Zannas AS, Kosyk O, Leung CS, Prolonged Glucocorticoid Exposure Does Not Accelerate Telomere Shortening in Cultured Human Fibroblasts Genes11:L141-L154 2020 |
| PubMed ID: 33261163 |
| |
| Caputo L, Granados A, Lenzi J, Rosa A, Ait-Si-Ali S, Puri PL, Albini S, Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFß-dependent pro-fibrotic signaling Skeletal muscle10:13 2019 |
| PubMed ID: 32359374 |
| |
| Dall'Agnese A, Caputo L, Nicoletti C, di Iulio J, Schmitt A, Gatto S, Diao Y, Ye Z, Forcato M, Perera R, Bicciato S, Telenti A, Ren B, Puri PL, Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation Molecular cell10:13 2019 |
| PubMed ID: 31519520 |
| |
| Sun G, Chiuppesi F, Chen X, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F, Shi Y, Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids Cell reports Medicine1:100002 2019 |
| PubMed ID: 33205055 |
| |
| Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V, Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties Nature communications11:2376 2019 |
| PubMed ID: 32398747 |
| |
| Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I, Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides Cell Metabolism28:817-832 2018 |
| PubMed ID: 30244971 |
| |
| Sanders YY, Liu H, Zhang X, Hecker L, Hernard K, Desai L, Liu G, Thannickal VJ, Histone modifications in senescence-associated resistance to apoptosis by oxidative stress Redox Biol1(1):8-16 2013 |
| PubMed ID: 24024133 |
| |
| Vallot C, Huret C, Lesecque Y, Resch A, Oudrhiri N, Bennaceur-Griscelli A, Duret L, Rougeulle C, XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells Nat Genet45(3):239-41 2013 |
| PubMed ID: 23334669 |
| |
| Mao Z, Ke Z, Gobunova V, Seluanov A., Replicatively senescent cells are arrested in G1 and G2 phases. Aging4:431-5 2012 |
| PubMed ID: 22745179 |
| |
| Cho JH, Saini DK, Karunarathne WK, Kalyanaraman V, Gautam N., Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit. Cell Signal23:785-93 2011 |
| PubMed ID: 21238584 |
| |
| Ghandhi SA, Ming L, Ivanov VN, Hei TK, Amundson SA, Regulation of early signaling and gene expression in the alpha-particle and bystander response of IMR-90 human fibroblasts BMC medical genomics3:31 2010 |
| PubMed ID: 20670442 |
| |
| Ivanov VN, Zhou H, Ghandhi SA, Karasic TB, Yaghoubian B, Amundson SA, Hei TK, Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission Cellular signalling22:1076-87 2010 |
| PubMed ID: 20206688 |
| |
| Eymery A, Souchier C, Vourc'h C, Jolly C, Heat shock factor 1 binds to and transcribes satellite II and III sequences at several pericentromeric regions in heat-shocked cells Experimental cell research316:1845-55 2009 |
| PubMed ID: 20152833 |
| |
| Gamerdinger M, Clement AB, Behl C, Cholesterol-Like Effects of Selective Cyclooxygenase Inhibitors and Fibrates on Cellular Membranes and Amyloid-beta Production Molecular pharmacology72:141-51 2007 |
| PubMed ID: 17395689 |
| |
| Milam JE, Keshamouni VG, Phan SH, Hu B, Gangireddy SR, Hogaboam CM, Standiford TJ, Thannickal VJ, Reddy RC, PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis American journal of physiology Lung cellular and molecular physiology294:L891-901 2007 |
| PubMed ID: 18162602 |
| |
| Atamna H, Newberry J, Erlitzki R, Schultz CS, Ames BN, Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts The Journal of nutrition137:25-30 2006 |
| PubMed ID: 17182796 |
| |
| Gosslau A, Chen M, Ho CT, Chen KY, A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts Br J Cancer92(3):513-21 2005 |
| PubMed ID: 15668717 |
| |
| Kern A, Roempp B, Prager K, Walter J, Behl C, Down-regulation of endogenous amyloid precursor protein processing due to cellular aging The Journal of biological chemistry281:2405-13 2005 |
| PubMed ID: 16303768 |
| |
| Kim TH, Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM, Glass CK, Rosenfeld MG, Myers RM, Ren B, Direct isolation and identification of promoters in the human genome Genome research15:830-9 2005 |
| PubMed ID: 15899964 |
| |
| White ES, Atrasz RG, Hu B, Phan SH, Stambolic V, Mak TW, Hogaboam CM, Flaherty KR, Martinez FJ, Kontos CD, Toews GB, Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10) American journal of respiratory and critical care medicine173:112-21 2005 |
| PubMed ID: 16179636 |
| |
| Yin Z, Watsky MA, Chloride channel activity in human lung fibroblasts and myofibroblasts American journal of physiology Lung cellular and molecular physiology288:L1110-6 2005 |
| PubMed ID: 15681397 |
| |
| Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T, Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev18(17):2108-19 2004 |
| PubMed ID: 15342490 |
| |
| White ES, Atrasz RG, Dickie EG, Aronoff DM, Stambolic V, Mak TW, Moore BB, Peters-Golden M, Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity American journal of respiratory cell and molecular biology32:135-41 2004 |
| PubMed ID: 15539459 |
| |
| Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN, ATM and ATR: sensing DNA damage. World J Gastroenterol10(2):155-60 2004 |
| PubMed ID: 14716813 |
| |
| Baird DM, Rowson J, Wynford-Thomas D, Kipling D, Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet33(2):203-7 2003 |
| PubMed ID: 12539050 |
| |
| Forsyth NR, Evans AP, Shay JW, Wright WE, Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell2(5):235-43 2003 |
| PubMed ID: 14570231 |
| |
| Li GZ, Eller MS, Firoozabadi R, Gilchrest BA, Evidence that exposure of the telomere 3' overhang sequence induces senescence Proceedings of the National Academy of Sciences of the United States of America100:527-31 2003 |
| PubMed ID: 12515865 |
| |
| Parada C, Hernandez Losa J, Guinea J, Sanchez-Arevalo V, Fernandez Soria V, Alvarez-Vallina L, Sanchez-Prieto R, Ramon Y Cajal S, Adenovirus E1a protein enhances the cytotoxic effects of the herpes thymidine kinase-ganciclovir system. Cancer Gene Ther10(2):152-60 2003 |
| PubMed ID: 12536204 |
| |
| Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE, Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase The Journal of biological chemistry278:12384-9 2003 |
| PubMed ID: 12531888 |
| |
| Borel F, Lohez OD, Lacroix FB, Margolis RL, Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells Proc Natl Acad Sci U S A99(15):9819-24 2002 |
| PubMed ID: 12119403 |
| |
| Deddish PA, Marcic BM, Tan F, Jackman HL, Chen Z, Erdos EG, Neprilysin inhibitors potentiate effects of bradykinin on b2 receptor. Hypertension39(2 Pt 2):619-23 2002 |
| PubMed ID: 11882619 |
| |
| Gabai VL, Mabuchi K, Mosser DD, Sherman MY, Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol22(10):3415-24 2002 |
| PubMed ID: 11971973 |
| |
| Shreeram S, Sparks A, Lane DP, Blow JJ, Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene21(43):6624-32 2002 |
| PubMed ID: 12242660 |
| |
| Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B, Kidd VJ, Mak TW, Ingram AJ, ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chemepub ahead of print:6624-32 2002 |
| PubMed ID: 11821415 |
| |
| Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J, SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev16(5):571-82 2002 |
| PubMed ID: 11877377 |
| |
| Zhang X, Shu L, Hosoi H, Murti KG, Houghton PJ, Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. J Biol Chem277(31):28127-34 2002 |
| PubMed ID: 12000755 |
| |
| Andreassen PR, Lohez OD, Lacroix FB, Margolis RL, Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell12(5):1315-28 2001 |
| PubMed ID: 11359924 |
| |
| Atamna H, Liu J, Ames BN, Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: revelance to aging. J Biol Chem276(51):48410-6 2001 |
| PubMed ID: 11598132 |
| |
| Atamna H, Robinson C, Ingersoll R, Elliott H, Ames BN, N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro. FASEB J15(12):2196-204 2001 |
| PubMed ID: 11641246 |
| |
| Danam RP, Howell SR, Remack JS, Brent TP, Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines. Int J Oncol18(6):1187-93 2001 |
| PubMed ID: 11351250 |
| |
| Guo W, Okamoto M, Park NH, Lee YM, Park NH, Cloning and expression of hamster telomerase catalytic subunit cDNA. Int J Mol Med8(1):73-8 2001 |
| PubMed ID: 11408953 |
| |
| Yang X, Taylor L, Polgar P, p53 down-regulates human bradykinin B1 receptor gene expression. J Cell Biochem82(1):38-45 2001 |
| PubMed ID: 11400161 |
| |
| Yang X, Taylor L, Yu J, Fenton MJ, Polgar P, Mediator caused induction of a human bradykinin B1 receptor minigene: participation of c-Jun in the process. J Cell Biochem82(1):163-70 2001 |
| PubMed ID: 11400173 |
| |
| Atamna H, Cheung I, Ames BN, A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A97(2):686-91 2000 |
| PubMed ID: 10639140 |
| |
| Atamna H, Paler-Martinez A, Ames BN, N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts. J Biol Chem275:6741-8 2000 |
| PubMed ID: 10702229 |
| |
| Ferbeyre G, de Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW, PML is induced by oncogenic ras and promotes premature senescence. Genes Dev14(16):2015-27 2000 |
| PubMed ID: 10950866 |
| |
| Yang X, He Z, Xin B, Cao L, LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression Oncogene19(16):2002-13 2000 |
| PubMed ID: 10803461 |
| |
| Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ, Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells. Free Radic Biol Med26(3-4):419-30 1999 |
| PubMed ID: 9895234 |
| |
| Chiou WJ, Wang J, Berg CE, Wu-Wong JR, SV40 virus transformation down-regulates endothelin receptor. Biochim Biophys Acta1450(1):35-44 1999 |
| PubMed ID: 10231553 |
| |
| Hay JG, Shapiro N, Sauthoff H, Heitner S, Phupakdi W, Rom WN, Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: the importance of the adenoviral E1b-55kD gene. Hum Gene Ther10(4):579-90 1999 |
| PubMed ID: 10094201 |
| |
| Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T, p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science283(5406):1321-5 1999 |
| PubMed ID: 10037601 |
| |
| Martelli F, Livingston DM, Regulation of endogenous E2F1 stability by the retinoblastoma family proteins. Proc Natl Acad Sci U S A96:2858-63 1999 |
| PubMed ID: 10077601 |
| |
| Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW, Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun254(3):795-803 1999 |
| PubMed ID: 9920820 |
| |
| Rudolph C, Adam G, Simm A, Determination of copy number of c-Myc protein per cell by quantitative Western blotting. Anal Biochem269(1):66-71 1999 |
| PubMed ID: 10094776 |
| |
| Suzuki K, Kazui T, Yoshida M, Uno T, Kobayashi T, Kimura T, Yoshida T, Sugimura H, Drug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro. Jpn J Clin Oncol29(7):323-31 1999 |
| PubMed ID: 10470656 |
| |
| Choung J, Taylor L, Thomas K, Zhou X, Kagan H, Yang X, Polgar P, Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. J Cell Biochem71(2):254-63 1998 |
| PubMed ID: 9779823 |
| |
| Lukiw WJ, Bazan NG, Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J Neurosci Res53(5):583-92 1998 |
| PubMed ID: 9726429 |
| |
| Stein GH, Dulic V, Molecular mechanisms for the senescent cell cycle arrest. J Investig Dermatol Symp Proc3(1):14-8 1998 |
| PubMed ID: 9732051 |
| |
| Yang X, Taylor L, Polgar P, Mechanisms in the transcriptional regulation of bradykinin B1 receptor gene expression. Identification of a minimum cell-type specific enhancer. J Biol Chem273(17):10763-70 1998 |
| PubMed ID: 9553142 |
| |
| Zhou X, Polgar P, Taylor L, Roles for interleukin-1beta, phorbol ester and a post-transcriptional regulator in the control of bradykinin B1 receptor gene expression Biochem J330 ( Pt 1):361-6 1998 |
| PubMed ID: 9461531 |
| |
| Baldin V, Cans C, Watanabe N, Ducommun B, Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition. Biochem Biophys Res Commun236(1):130-4 1997 |
| PubMed ID: 9223439 |
| |
| Inamura N, Asano M, Kayakiri H, Hatori C, Oku T, Nakahara K, Characterization of FR173657, a novel nonpeptide B2 antagonist: in vitro and in vivo studies. Can J Physiol Pharmacol75(6):622-8 1997 |
| PubMed ID: 9276139 |
| |
| Jiang WQ, Ringertz N, Altered distribution of the promyelocytic leukemia-associated protein is associated with cellular senescence. Cell Growth Differ8(5):513-22 1997 |
| PubMed ID: 9213441 |
| |
| Krupsky M, Kuang PP, Goldstein RH, Regulation of type I collagen mRNA by amino acid deprivation in human lung fibroblasts. J Biol Chem272:13864-8 1997 |
| PubMed ID: 9153245 |
| |
| Makarov VL, Hirose Y, Langmore JP, Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell88:657-66 1997 |
| PubMed ID: 9054505 |
| |
| Rodriguez A, Webster P, Ortego J, Andrews NW, Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol137(1):93-104 1997 |
| PubMed ID: 9105039 |
| |
| Saito H, Papaconstantinou J, Sato H, Goldstein S, Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence. J Biol Chem272:8157-60 1997 |
| PubMed ID: 9079631 |
| |
| Wang X, Gorospe M, Huang Y, Holbrook NJ, p27Kip1 overexpression causes apoptotic death of mammalian cells. Oncogene15(24):2991-7 1997 |
| PubMed ID: 9416843 |
| |
| Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL, Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. Eur J Cell Biol69(3):236-44 1996 |
| PubMed ID: 8900488 |
| |
| Harris LC, Remack JS, Houghton PJ, Brent TP, Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene. Cancer Res56(9):2029-32 1996 |
| PubMed ID: 8616846 |
| |
| Harris LC, von Wronski MA, Venable CC, Remack JS, Howell SR, Brent TP, Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts. Carcinogenesis17(2):219-24 1996 |
| PubMed ID: 8625442 |
| |
| Harrison L, Galanopoulos T, Ascione AG, Antoniades HN, Demple B, Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis. Carcinogenesis17(2):377-81 1996 |
| PubMed ID: 8625467 |
| |
| Roy R, Polgar P, Wang Y, Goldstein RH, Taylor L, Kagan HM, Regulation of lysyl oxidase and cyclooxygenase expression in human lung fibroblasts: interactions among TGF-beta, IL-1 beta, and prostaglandin E. J Cell Biochem62(3):411-7 1996 |
| PubMed ID: 8872612 |
| |
| Baldin V, Ducommun B, Subcellular localisation of human wee1 kinase is regulated during the cell cycle. J Cell Sci108 ( Pt 6):2425-32 1995 |
| PubMed ID: 7673359 |
| |
| Borsi L, Balza E, Gaggero B, Allemanni G, Zardi L, The alternative splicing pattern of the tenascin-C pre-mRNA is controlled by the extracellular pH. J Biol Chem270:6243-5 1995 |
| PubMed ID: 7534307 |
| |
| Duan C, Clemmons DR, Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression. J Biol Chem270:24844-51 1995 |
| PubMed ID: 7559606 |
| |
| Halle JP, Schmidt C, Adam G, Changes of the methylation pattern of the c-myc gene during in vitro aging of IMR90 human embryonic fibroblasts. Mutat Res316(4):157-71 1995 |
| PubMed ID: 7776985 |
| |
| Hendil KB, Kristensen P, Uerkvitz W, Human proteasomes analysed with monoclonal antibodies. Biochem J305 ( Pt 1):245-52 1995 |
| PubMed ID: 7826336 |
| |
| Jesudasan RA, Rahman RA, Chandrashekharappa S, Evans GA, Srivatsan ES, Deletion and translocation of chromosome 11q13 sequences in cervical carcinoma cell lines [see comments] Am J Hum Genet56:705-15 1995 |
| PubMed ID: 7887426 |
| |
| Puglielli L, Rigotti A, Greco AV, Santos MJ, Nervi F, Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts. J Biol Chem270:18723-6 1995 |
| PubMed ID: 7642518 |
| |
| Saito H, Hammond AT, Moses RE, The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives. Exp Cell Res217(2):272-9 1995 |
| PubMed ID: 7698226 |
| |
| Chang ZF, Huang DY, Decline of protein kinase C activation in response to growth stimulation during senescence of IMR-90 human diploid fibroblasts. Biochem Biophys Res Commun200:16-27 1994 |
| PubMed ID: 8166683 |
| |
| Li Y, Jenkins CW, Nichols MA, Xiong Y, Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene9(8):2261-8 1994 |
| PubMed ID: 7913544 |
| |
| Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W, The relative expression of human histone H2A genes is similar in different types of proliferating cells. DNA Cell Biol13(2):161-70 1994 |
| PubMed ID: 8179821 |
| |
| Rubelj I, Pereira-Smith OM, SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence. Exp Cell Res211:82-9 1994 |
| PubMed ID: 7510251 |
| |
| Sagesaka T, Boubnov N, Okuyama T, Paulus H, Sarkar N, Deoxyribonucleic acid replication in fetal cells. Am J Obstet Gynecol170(2):468-73 1994 |
| PubMed ID: 8116699 |
| |
| Saito H, Grompe M, Neeley TL, Jakobs PM, Moses RE, Fanconi anemia cells have a normal gene structure for topoisomerase I. Hum Genet93:583-6 1994 |
| PubMed ID: 8168839 |
| |
| Vannini F, Meacci E, Vasta V, Farnararo M, Bruni P, Involvement of protein kinase C and arachidonate signaling pathways in the alteration of proliferative response of senescent IMR-90 human fibroblasts. Mech Ageing Dev76:101-11 1994 |
| PubMed ID: 7885058 |
| |
| Chang ZF, Cheng SM, Constitutive overexpression of DNA binding activity to the distal CCAAT box of human thymidine kinase promoter in human tumor cell lines. Cancer Res53:3253-6 1993 |
| PubMed ID: 8324736 |
| |
| Jackson BA, Goldstein RH, Roy R, Cozzani M, Taylor L, Polgar P, Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture. Biochem Biophys Res Commun197(3):1465-74 1993 |
| PubMed ID: 8280164 |
| |
| Kelley J, Shull S, Walsh JJ, Cutroneo KR, Absher M, Auto-induction of transforming growth factor-beta in human lung fibroblasts. Am J Respir Cell Mol Biol8(4):417-24 1993 |
| PubMed ID: 8476635 |
| |
| Manfioletti G, Brancolini C, Avanzi G, Schneider C, The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol13(8):4976-85 1993 |
| PubMed ID: 8336730 |
| |
| Schaefer DI, Livanos EM, White AE, Tlsty TD, Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts. Cancer Res53:4946-51 1993 |
| PubMed ID: 8402685 |
| |
| Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB, cDNA clones contain autonomous replication activity. Biochim Biophys Acta1174(3):241-57 1993 |
| PubMed ID: 7690594 |
| |
| Wu C, Zannis-Hadjopoulos M, Price GB, In vivo activity for initiation of DNA replication resides in a transcribed region of the human genome. Biochim Biophys Acta1174(3):258-66 1993 |
| PubMed ID: 8373803 |
| |
| Baenziger NL, Jong YJ, Yocum SA, Dalemar LR, Wilhelm B, Vavrek R, Stewart JM, Diversity of B2 bradykinin receptors with nanomolar affinity expressed in passaged IMR90 human lung fibroblasts. Eur J Cell Biol58(1):71-80 1992 |
| PubMed ID: 1322819 |
| |
| Fukunaga N, Burrows HL, Meyers M, Schea RA, Boothman DA, Enhanced induction of tissue-type plasminogen activator in normal human cells compared to cancer-prone cells following ionizing radiation. Int J Radiat Oncol Biol Phys24(5):949-57 1992 |
| PubMed ID: 1447036 |
| |
| Sakai T, Satoh K, Narumi K, Abe T, Motomiya M, Cloning of 67 kDa-laminin receptor cDNA and its expression in various human lung cancer cell lines. Nihon Kyobu Shikkan Gakkai Zasshi30(3):402-6 1992 |
| PubMed ID: 1314918 |
| |
| Satoh K, Narumi K, Sakai T, Abe T, Kikuchi T, Matsushima K, Sindoh S, Motomiya M, Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. Cancer Lett62(3):199-203 1992 |
| PubMed ID: 1534510 |
| |
| Yang CL, Chang LS, Zhang P, Hao H, Zhu L, Toomey NL, Lee MY, Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta. Nucleic Acids Res20(4):735-45 1992 |
| PubMed ID: 1542570 |
| |
| Magnuson VL, Young M, Schattenberg DG, Mancini MA, Chen DL, Steffensen B, Klebe RJ, The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors. J Biol Chem266:14654-62 1991 |
| PubMed ID: 1713586 |
| |
| Paw BH, Wood LC, Neufeld EF, A third mutation at the CpG dinucleotide of codon 504 and a silent mutation at codon 506 of the HEX A gene. Am J Hum Genet48:1139-46 1991 |
| PubMed ID: 1827944 |
| |
| Saito H, Moses RE, Immortalization of Werner syndrome and progeria fibroblasts Experimental cell research192:373-9 1991 |
| PubMed ID: 1671011 |
| |
| Shigeoka H, Yang HC, Regulation of the retinoblastoma anti-oncogene in aging human diploid fibroblasts. Mech Ageing Dev57:63-70 1991 |
| PubMed ID: 2002699 |
| |
| Solem M, Helmrich A, Collodi P, Barnes D, Human and mouse S-protein mRNA detected in northern blot experiments and evidence for the gene encoding S-protein in mammals by Southern blot analysis. Mol Cell Biochem100(2):141-9 1991 |
| PubMed ID: 2008176 |
| |
| Sun Y, Moses RE, Reactivation of psoralen-reacted plasmid DNA in Fanconi anemia, xeroderma pigmentosum, and normal human fibroblast cells. Somat Cell Mol Genet17:229-38 1991 |
| PubMed ID: 2047939 |
| |
| Wu CH, Walton CM, Wu GY, Propeptide-mediated regulation of procollagen synthesis in IMR-90 human lung fibroblast cell cultures. Evidence for transcriptional control. J Biol Chem266:2983-7 1991 |
| PubMed ID: 1993671 |
| |
| Kunisada T, Miller CD, Schneider EL, Ultraviolet light-induced DNA damage in transcribed sequences: no change in repair with age. Mutat Res237:75-81 1990 |
| PubMed ID: 2164149 |
| |
| Mukherjee AB, Wallace KC, Changes in frequency and localization of human X- and Y-chromatin bodies at interphase during in vitro cellular aging. Mech Ageing Dev53(1):61-71 1990 |
| PubMed ID: 2325441 |
| |
| Pereira-Smith OM, Stein GH, Robetorye S, Meyer-Demarest S, Immortal phenotype of the HeLa variant D98 is recessive in hybrids formed with normal human fibroblasts. J Cell Physiol143:222-5 1990 |
| PubMed ID: 2332448 |
| |
| Sharma PM, Reddy GR, Babior BM, McLachlan A, Alternative splicing of the transcript encoding the human muscle isoenzyme of phosphofructokinase. J Biol Chem265:9006-10 1990 |
| PubMed ID: 2140567 |
| |
| Shigeoka H, Yang HC, Early kinase C dependent events in aging human diploid fibroblasts. Mech Ageing Dev55:49-59 1990 |
| PubMed ID: 1698234 |
| |
| Vlahos NS, Futscher BW, Hora NK, Trent JM, Erickson LC, Gene amplification affecting O(6)-alkylguanine-DNA alkyltransferase activity is not detected in nitrosourea resistant or sensitive human cell lines. Carcinogenesis11:479-83 1990 |
| PubMed ID: 2311191 |
| |
| Absher M, Woodcock-Mitchell J, Mitchell J, Baldor L, Low R, Warshaw D, Characterization of vascular smooth muscle cell phenotype in long-term culture. In Vitro Cell Dev Biol25:183-92 1989 |
| PubMed ID: 2921236 |
| |
| Babich MA, Day RS 3d, Synergistic killing of virus-transformed human cells with interferon and N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis10:265-8 1989 |
| PubMed ID: 2463881 |
| |
| Bannai S, Sato H, Ishii T, Sugita Y, Induction of cystine transport activity in human fibroblasts by oxygen. J Biol Chem264:18480-4 1989 |
| PubMed ID: 2808385 |
| |
| Boothman DA, Bouvard I, Hughes EN, Identification and characterization of X-ray-induced proteins in human cells. Cancer Res49:2871-8 1989 |
| PubMed ID: 2720648 |
| |
| Ethier MF, Hickler RB, Dobson JG Jr, Aging increases adenosine and inosine release by human fibroblast cultures. Mech Ageing Dev50:159-68 1989 |
| PubMed ID: 2601414 |
| |
| Gibson JM, Milam SB, Klebe RJ, Late passage cells display an increase in contractile behavior. Mech Ageing Dev48:101-10 1989 |
| PubMed ID: 2739467 |
| |
| Liu AY, Bae-Lee MS, Choi HS, Li BS, Heat shock induction of HSP 89 is regulated in cellular aging. Biochem Biophys Res Commun162:1302-10 1989 |
| PubMed ID: 2764934 |
| |
| Liu AY, Lin Z, Choi HS, Sorhage F, Li B, Attenuated induction of heat shock gene expression in aging diploid fibroblasts. J Biol Chem264:12037-45 1989 |
| PubMed ID: 2745427 |
| |
| Matsumura T, Malik F, Holliday R, Levels of DNA methylation in diploid and SV40 transformed human fibroblasts. Exp Gerontol24:477-81 1989 |
| PubMed ID: 2561103 |
| |
| McNearney T, Ballard L, Seya T, Atkinson JP, Membrane cofactor protein of complement is present on human fibroblast, epithelial, and endothelial cells. J Clin Invest84:538-45 1989 |
| PubMed ID: 2474570 |
| |
| Misra BC, Srivatsan ES, Localization of HeLa cell tumor-suppressor gene to the long arm of chromosome II. Am J Hum Genet45:565-77 1989 |
| PubMed ID: 2577469 |
| |
| Paw BH, Kaback MM, Neufeld EF, Molecular basis of adult-onset and chronic GM2 gangliosidoses in patients of Ashkenazi Jewish origin: substitution of serine for glycine at position 269 of the alpha-subunit of beta-hexosaminidase [published erratum appears in Proc Natl Acad Sci U S A 1989 Jul;86(14):5625] Proc Natl Acad Sci U S A86:2413-7 1989 |
| PubMed ID: 2522660 |
| |
| Quon DV, Proia RL, Fowler AV, Bleibaum J, Neufeld EF, Proteolytic processing of the beta-subunit of the lysosomal enzyme, beta-hexosaminidase, in normal human fibroblasts. J Biol Chem264:3380-4 1989 |
| PubMed ID: 2521634 |
| |
| Chang ZF, Chen KY, Regulation of ornithine decarboxylase and other cell cycle-dependent genes during senescence of IMR-90 human diploid fibroblasts. J Biol Chem263:11431-5 1988 |
| PubMed ID: 3403538 |
| |
| Dresler SL, Frattini MG, Analysis of butylphenyl-guanine, butylphenyl-deoxyguanosine, and butylphenyl-deoxyguanosine triphosphate inhibition of DNA replication and ultraviolet-induced DNA repair synthesis using permeable human fibroblasts. Biochem Pharmacol37:1033-7 1988 |
| PubMed ID: 3355581 |
| |
| Little LE, Lau MM, Quon DV, Fowler AV, Neufeld EF, Proteolytic processing of the alpha-chain of the lysosomal enzyme, beta- hexosaminidase, in normal human fibroblasts. J Biol Chem263:4288-92 1988 |
| PubMed ID: 2964446 |
| |
| Myerowitz R, Splice junction mutation in some Ashkenazi Jews with Tay-Sachs disease: evidence against a single defect within this ethnic group. Proc Natl Acad Sci U S A85:3955-9 1988 |
| PubMed ID: 3375249 |
| |
| Myerowitz R, Costigan FC, The major defect in Ashkenazi Jews with Tay-Sachs disease is an insertion in the gene for the alpha-chain of beta-hexosaminidase. J Biol Chem263:18587-9 1988 |
| PubMed ID: 2848800 |
| |
| Noda A, Replicon initiation in normal human cells and in ataxia telangiectasia cells: its differential inhibition by cycloheximide and bleomycin. Cell Biol Int Rep12:943-50 1988 |
| PubMed ID: 2465834 |
| |
| Paw BH, Neufeld EF, Normal transcription of the beta-hexosaminidase alpha-chain gene in the Ashkenazi Tay-Sachs mutation. J Biol Chem263(6):3012-5 1988 |
| PubMed ID: 2449434 |
| |
| Santos MJ, Imanaka T, Shio H, Lazarow PB, Peroxisomal integral membrane proteins in control and Zellweger fibroblasts. J Biol Chem263:10502-9 1988 |
| PubMed ID: 3292528 |
| |
| Slot LA, Hendil KB, Alpha 2-macroglobulin used to isolate intracellular endopeptidases from mammalian cells in culture. Biochem J255(2):437-43 1988 |
| PubMed ID: 2462415 |
| |
| Chen KY, Chang ZF, A marked increase of fucosylation of glycoproteins in IMR-90 human diploid fibroblasts during senescence in vitro. Biochem Biophys Res Commun142:767-74 1987 |
| PubMed ID: 3827902 |
| |
| Constantopoulos G, McGarrity GJ, Activities of oxidative enzymes in mycoplasmas. J Bacteriol169:2012-6 1987 |
| PubMed ID: 3571159 |
| |
| Cowles EA, Brauker JH, Anderson RL, Turnover of sulfated glycosaminoglycans in fibroblasts derived from patients with Werner's syndrome. Exp Cell Res168:347-57 1987 |
| PubMed ID: 3100317 |
| |
| Dresler SL, Robinson-Hill RM, Direct inhibition of u.v.-induced DNA excision repair in human cells by novobiocin, coumermycin and nalidixic acid. Carcinogenesis8:813-7 1987 |
| PubMed ID: 3608079 |
| |
| Fine A, Goldstein RH, The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts. J Biol Chem262:3897-902 1987 |
| PubMed ID: 3493244 |
| |
| Hara H, Kaji H, Random integration of SV40 in SV40-transformed, immortalized human fibroblasts. Exp Cell Res168:531-8 1987 |
| PubMed ID: 3026824 |
| |
| Mann PL, Lopez-Colberg I, Kelley RO, Cell surface oligosaccharide modulation during differentiation. I. Modulation of lectin binding. Mech Ageing Dev38:207-17 1987 |
| PubMed ID: 3114574 |
| |
| Mann PL, Swartz CM, Kelley RO, Cell surface oligosaccharide modulation during differentiation. II. Membrane mobility of oligosaccharide lectin conjugates. Mech Ageing Dev38:219-30 1987 |
| PubMed ID: 3041129 |
| |
| Mayer PJ, Bradley MO, Nichols WW, The effect of mild hypothermia (34 degrees C) and mild hyperthermia (39 degrees C) on DNA damage, repair and aging of human diploid fibroblasts. Mech Ageing Dev39:203-22 1987 |
| PubMed ID: 3626641 |
| |
| Nakamura KD, Hart RW, Comparison of proto oncogene expression in seven primate fibroblast cultures. Mech Ageing Dev39:177-87 1987 |
| PubMed ID: 3626640 |
| |
| Pettenati MJ, Le Beau MM, Lemons RS, Shima EA, Kawasaki ES, Larson RA, Sherr CJ, Diaz MO, Rowley JD, Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc Natl Acad Sci U S A84:2970-4 1987 |
| PubMed ID: 3495006 |
| |
| Sottile J, Hoyle M, Millis AJ, Enhanced synthesis of a Mr = 55,000 dalton peptide by senescent human fibroblasts. J Cell Physiol131:210-7 1987 |
| PubMed ID: 3584248 |
| |
| Wilhelm SM, Collier IE, Kronberger A, Eisen AZ, Marmer BL, Grant GA, Bauer EA, Goldberg GI, Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells. Proc Natl Acad Sci U S A84:6725-9 1987 |
| PubMed ID: 3477804 |
| |
| Zokaeem G, Bayleran J, Kaplan P, Hechtman P, Neufeld EF, A shortened beta-hexosaminidase alpha-chain in an Italian patient with infantile Tay-Sachs disease. Am J Hum Genet40:537-47 1987 |
| PubMed ID: 2954459 |
| |
| Bannai S, Exchange of cystine and glutamate across plasma membrane of human fibroblasts. J Biol Chem261:2256-63 1986 |
| PubMed ID: 2868011 |
| |
| Bunn CL, Baron JI, Mitchell D, Inherent resistance of HeLa cell derivatives to paromomycin. In Vitro Cell Dev Biol22:381-6 1986 |
| PubMed ID: 3015861 |
| |
| Chen KY, Chang ZF, Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts. J Cell Physiol128:27-32 1986 |
| PubMed ID: 3087998 |
| |
| Chen KY, Chang ZF, Liu AY, Changes of serum-induced ornithine decarboxylase activity and putrescine content during aging of IMR-90 human diploid fibroblasts. J Cell Physiol129:142-6 1986 |
| PubMed ID: 3771651 |
| |
| Dean R, Kim SS, Delgado D, Expression of c-myc oncogene in human fibroblasts during in vitro senescence. Biochem Biophys Res Commun135:105-9 1986 |
| PubMed ID: 3954759 |
| |
| Delgado D, Raymond L, Dean R, C-ras expression decreases during in vitro senescence in human fibroblasts. Biochem Biophys Res Commun137:917-21 1986 |
| PubMed ID: 3524568 |
| |
| Dice JF, Chiang HL, Spencer EP, Backer JM, Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide [published erratum appears in J Biol Chem 1986 Oct 5;261(28):13387] J Biol Chem261:6853-9 1986 |
| PubMed ID: 3700419 |
| |
| Gibson NW, Hartley J, La France RJ, Vaughan K, Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles. Carcinogenesis7:259-65 1986 |
| PubMed ID: 3948314 |
| |
| Gibson NW, Hartley JA, Kohn KW, DNA reactivity and in vitro cytotoxicity of the novel antitumor agent 1,5,2,4-dioxadithiepane-2,2,4,4-tetraoxide (NSC-348948) in human embryo cells. Cancer Res46:1679-83 1986 |
| PubMed ID: 3509975 |
| |
| Goldstein RH, Sakowski S, Meeker D, Franzblau C, Polgar P, The effect of prostaglandin E2 (PGE2) on amino acid uptake and protein formation by lung fibroblasts. J Biol Chem261:8734-7 1986 |
| PubMed ID: 3459727 |
| |
| Henner WD, Blazka ME, Hypersensitivity of cultured ataxia-telangiectasia cells to etoposide. J Natl Cancer Inst76(6):1007-11 1986 |
| PubMed ID: 2423735 |
| |
| Hiramatsu K, Masuda M, Yoshikura H, Mode of transmission of human T-cell leukemia virus type I (HTLV I) in a human promyelocytic leukemia HL60 cell. Int J Cancer37(4):601-6 1986 |
| PubMed ID: 3007376 |
| |
| Hiramatsu K, Yoshikura H, Frequent partial deletion of human adult T-cell leukemia virus type I proviruses in experimental transmission: pattern and possible implication. J Virol58(2):508-12 1986 |
| PubMed ID: 3009864 |
| |
| Krauss SW, Linn S, Studies of DNA polymerases alpha and beta from cultured human cells in various replicative states. J Cell Physiol126:99-106 1986 |
| PubMed ID: 3944201 |
| |
| Krusius T, Ruoslahti E, Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc Natl Acad Sci U S A83:7683-7 1986 |
| PubMed ID: 3484330 |
| |
| Kulesh DA, Greene JJ, Shape-dependent regulation of proliferation in normal and malignant human cells and its alteration by interferon. Cancer Res46:2793-7 1986 |
| PubMed ID: 2421883 |
| |
| Liu AY, Chang ZF, Chen KY, Increased level of cAMP-dependent protein kinase in aging human lung fibroblasts. J Cell Physiol128:149-54 1986 |
| PubMed ID: 3015985 |
| |
| Mayer PJ, Bradley MO, Nichols WW, No change in DNA damage or repair of single- and double-strand breaks as human diploid fibroblasts age in vitro. Exp Cell Res166:497-509 1986 |
| PubMed ID: 3743669 |
| |
| Myerowitz R, Hogikyan ND, Different mutations in Ashkenazi Jewish and non-Jewish French Canadians with Tay-Sachs disease. Science232:1646-8 1986 |
| PubMed ID: 3754980 |
| |
| Ohno T, Kako R, Sato C, Ohkawa A, Distinction of G0 cells from senescent cells in cultures of non-cycling human fetal lung fibroblasts by anti-MAP-1 monoclonal antibody staining. Exp Cell Res163:309-16 1986 |
| PubMed ID: 3956580 |
| |
| Pothoulakis C, Barone LM, Ely R, Faris B, Clark ME, Franzblau C, LaMont JT, Purification and properties of Clostridium difficile cytotoxin B. J Biol Chem261:1316-21 1986 |
| PubMed ID: 3944088 |
| |
| Ramanathan B, Smerdon MJ, Changes in nuclear protein acetylation in u.v.-damaged human cells. Carcinogenesis7:1087-94 1986 |
| PubMed ID: 3087643 |
| |
| Sanford KK, Parshad R, Stanbridge EJ, Frost JK, Jones GM, Wilkinson JE, Tarone RE, Chromosomal radiosensitivity during the G2 cell cycle period and cytopathology of human normal x tumor cell hybrids. Cancer Res46:2045-9 1986 |
| PubMed ID: 3948180 |
| |
| Slot LA, Lauridsen AM, Hendil KB, Intracellular protein degradation in serum-deprived human fibroblasts. Biochem J237(2):491-8 1986 |
| PubMed ID: 2432873 |
| |
| Smerdon MJ, Completion of excision repair in human cells. Relationship between ligation and nucleosome formation. J Biol Chem261:244-52 1986 |
| PubMed ID: 3941074 |
| |
| Stein GH, Atkins L, Beeson M, Gordon L, Quiescent human diploid fibroblasts. Common mechanism for inhibition of DNA replication in density-inhibited and serum-deprived cells. Exp Cell Res162:255-60 1986 |
| PubMed ID: 2998845 |
| |
| Yen PH, Mohandas T, Shapiro LJ, Stability of DNA methylation of the human hypoxanthine phosphoribosyltransferase gene. Somat Cell Mol Genet12:153-61 1986 |
| PubMed ID: 3008350 |
| |
| Birckbichler PJ, Upchurch HF, Patterson MK Jr, Conway E, A monoclonal antibody to cellular transglutaminase. Hybridoma4(2):179-86 1985 |
| PubMed ID: 2861155 |
| |
| Dresler SL, Stimulation of deoxyribonucleic acid excision repair in human fibroblasts pretreated with sodium butyrate. Biochemistry24:6861-9 1985 |
| PubMed ID: 4074730 |
| |
| Finlay CA, Rosner BA, Miller JE, Wallace JM, Cristofalo VJ, Enhanced proliferation of WI38 cells in the presence of glucocorticoid- conditioned medium. Exp Cell Res156:462-70 1985 |
| PubMed ID: 3967687 |
| |
| Hasegawa N, Hanaoka F, Yamada M, Does capacity of DNA replication change during in vitro ageing? Exp Cell Res156:478-86 1985 |
| PubMed ID: 3967689 |
| |
| Kelley RO, Mann PL, Perdue BD, Marek LF, Reduction of filamin in late passage human diploid fibroblasts (IMR-90). Mech Ageing Dev30:79-98 1985 |
| PubMed ID: 3889515 |
| |
| Kondo H, Kasuga H, Noumura T, The heterogeneity of human fibroblasts as determined from the effects of hydrocortisone on cell growth and specific dexamethasone binding. Exp Cell Res158:342-8 1985 |
| PubMed ID: 4007059 |
| |
| Lan SY, Smerdon MJ, A nonuniform distribution of excision repair synthesis in nucleosome core DNA. Biochemistry24:7771-83 1985 |
| PubMed ID: 4092038 |
| |
| McElligott MA, Miao P, Dice JF, Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts. J Biol Chem260:11986-93 1985 |
| PubMed ID: 4044585 |
| |
| Netland PA, Dice JF, Red blood cell-mediated microinjection: methodological considerations. Anal Biochem150:214-20 1985 |
| PubMed ID: 4083480 |
| |
| Ohno T, Ohkawa A, Sato C, Factors controlling the appearance of the immunofluorescent nuclear dots revealed with monoclonal antibody against microtubule-associated protein-1. Exp Cell Res158:558-62 1985 |
| PubMed ID: 3891390 |
| |
| Santos MJ, Ojeda JM, Garrido J, Leighton F, Peroxisomal organization in normal and cerebrohepatorenal (Zellweger) syndrome fibroblasts. Proc Natl Acad Sci U S A82:6556-60 1985 |
| PubMed ID: 2995971 |
| |
| Stein GH, SV40-transformed human fibroblasts: evidence for cellular aging in pre- crisis cells. J Cell Physiol125:36-44 1985 |
| PubMed ID: 2995426 |
| |
| Takahashi S, Nakagawa S, Zeydel M, Bhargava G, Ammonia production by IMR-90 fibroblast cultures: effects of ammonia on glutathione, gamma-glutamyl transpeptidase, lysosomal enzymes, and cell division. J Cell Physiol125:107-14 1985 |
| PubMed ID: 2864350 |
| |
| Van Riper DA, Absher MP, Lenox RH, Muscarinic receptors on intact human fibroblasts. Absence of receptor activity in adult skin cells. J Clin Invest76:882-6 1985 |
| PubMed ID: 2993368 |
| |
| Watkins JF, Smerdon MJ, Nucleosome rearrangement in vitro. 1. Two phases of salt-induced nucleosome migration in nuclei. Biochemistry24:7279-87 1985 |
| PubMed ID: 4084581 |
| |
| Watkins JF, Smerdon MJ, Nucleosome rearrangement in vitro. 2. Formation of nucleosomes in newly repaired regions of DNA. Biochemistry24:7288-95 1985 |
| PubMed ID: 4084582 |
| |
| White FA, Bunn CL, Restriction enzyme analysis of mitochondrial DNA in aging human cells. Mech Ageing Dev30:153-68 1985 |
| PubMed ID: 2991673 |
| |
| Absher M, Cristofalo VJ, Analysis of cell division by time-lapse cinematographic studies of hydrocortisone-treated embryonic lung fibroblasts. J Cell Physiol119:315-9 1984 |
| PubMed ID: 6725417 |
| |
| Asselineau D, Bell E, Prolylhydroxylase activation in IMR 90 fibroblasts: state of differentiation rather than population doubling level determines requirements for enzyme activation. Mech Ageing Dev25:257-66 1984 |
| PubMed ID: 6328135 |
| |
| Balin AK, Fisher AJ, Carter DM, Oxygen modulates growth of human cells at physiologic partial pressures. J Exp Med160(1):152-66 1984 |
| PubMed ID: 6736869 |
| |
| Bienkowski RS, Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. J Cell Physiol121:152-8 1984 |
| PubMed ID: 6384240 |
| |
| Goldstein RH, Wall M, Activation of protein formation and cell division by bradykinin and des- Arg9-bradykinin. J Biol Chem259:9263-8 1984 |
| PubMed ID: 6430899 |
| |
| Hasegawa N, Hanaoka F, Yamada M, Increased unscheduled DNA synthesis in aged human diploid fibroblasts. Mech Ageing Dev25:297-305 1984 |
| PubMed ID: 6738123 |
| |
| Myerowitz R, Proia RL, cDNA clone for the alpha-chain of human beta-hexosaminidase: deficiency of alpha-chain mRNA in Ashkenazi Tay-Sachs fibroblasts. Proc Natl Acad Sci U S A81:5394-8 1984 |
| PubMed ID: 6236461 |
| |
| Ohno T, Nishimura T, Nakano K, Kaneko I, Differential recovery from potentially lethal damage in normal human lung fibroblasts after irradiation with 60Co gamma-rays and accelerated N-ion beam. Int J Radiat Biol Relat Stud Phys Chem Med45:21-6 1984 |
| PubMed ID: 6607229 |
| |
| Ohno T, Yamada M, Growth stimulation by direct cell-cell contact (contact stimulation) in normal human lung fibroblasts. Biomed Pharmacother38:337-43 1984 |
| PubMed ID: 6525431 |
| |
| Ohno T, Yamaguchi N, Life span elongation of Werner's syndrome fibroblasts by co-culture with origin-defective SV-40 DNA transformed cells. Hum Genet68:209-10 1984 |
| PubMed ID: 6094336 |
| |
| Okada AA, Dice JF, Altered degradation of intracellular proteins in aging human fibroblasts. Mech Ageing Dev26:341-56 1984 |
| PubMed ID: 6482527 |
| |
| Proia RL, d'Azzo A, Neufeld EF, Association of alpha- and beta-subunits during the biosynthesis of beta- hexosaminidase in cultured human fibroblasts. J Biol Chem259:3350-4 1984 |
| PubMed ID: 6230359 |
| |
| Sariban E, Erickson LC, Kohn KW, Effects of carbamoylation on cell survival and DNA repair in normal human embryo cells (IMR-90) treated with various 1-(2-chloroethyl)-1- nitrosoureas. Cancer Res44:1352-7 1984 |
| PubMed ID: 6704956 |
| |
| Smith CA, Okumoto DS, Nature of DNA repair synthesis resistant to inhibitors of polymerase alpha in human cells. Biochemistry23:1383-91 1984 |
| PubMed ID: 6426505 |
| |
| Straus DS, Pang KJ, Effects of bradykinin on DNA synthesis in resting NIL8 hamster cells and human fibroblasts. Exp Cell Res151:87-95 1984 |
| PubMed ID: 6141950 |
| |
| Tomkins DJ, Sisken JE, Abnormalities in the cell-division cycle in Roberts syndrome fibroblasts: a cellular basis for the phenotypic characteristics? Am J Hum Genet36:1332-40 1984 |
| PubMed ID: 6517054 |
| |
| Torrelio BM, Paz MA, Gallop PM, Cellular proliferation and hypusine synthesis. Exp Cell Res154:454-63 1984 |
| PubMed ID: 6434336 |
| |
| Yoshikura H, Nishida J, Yoshida M, Kitamura Y, Takaku F, Ikeda S, Isolation of HTLV derived from Japanese adult T-cell leukemia patients in human diploid fibroblast strain IMR90 and the biological characters of the infected cells. Int J Cancer33(6):745-9 1984 |
| PubMed ID: 6329966 |
| |
| Absher M, Sylwester D, Hart BA, Time-lapse cinematographic analysis of beryllium--lung fibroblast interactions. Environ Res30:34-43 1983 |
| PubMed ID: 6832110 |
| |
| Backer JM, Bourret L, Dice JF, Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids. Proc Natl Acad Sci U S A80:2166-70 1983 |
| PubMed ID: 6572969 |
| |
| Bemiller P, Kraus ER Jr, The effect of clinical and subclinical concentrations of lead on the in vitro aging of human fibroblasts. Mech Ageing Dev22:79-87 1983 |
| PubMed ID: 6621113 |
| |
| Chung HR, Albanese EA, Studzinski GP, Differential effect of coformycin on the cell cycle traverse of normal and simian virus 40-transformed human fibroblasts. Cancer Res43:1269-74 1983 |
| PubMed ID: 6297723 |
| |
| Halton DM, Peterson WD Jr, Hukku B, Cell culture quality control by rapid isoenzymatic characterization. In Vitro19:16-24 1983 |
| PubMed ID: 6401685 |
| |
| Hildebran JN, Absher M, Low RB, Altered rates of collagen synthesis in in vitro aged human lung fibroblasts. In Vitro19:307-14 1983 |
| PubMed ID: 6852832 |
| |
| nn JM, Bodner JB, Knowles SE, Ballard FJ, Inhibition of protein breakdown by epidermal growth factor in IMR90 human fibroblasts and other mammalian cell lines Biochem J210(1):251-8 1983 |
| PubMed ID: 6303314 |
| |
| Roff CF, Wozniak RW, Blenis J, Wang JL, The effect of mannose6-phosphate on the turnover of cell surface glycosaminoglycans. Exp Cell Res144:333-44 1983 |
| PubMed ID: 6404644 |
| |
| Stein GH, Human diploid fibroblasts (HDF) can induce DNA synthesis in cycling HDF but not in quiescent HDF or senescent HDF. Exp Cell Res144:468-71 1983 |
| PubMed ID: 6840221 |
| |
| Wedel N, Toselli P, Pothoulakis C, Faris B, Oliver P, Franzblau C, LaMont T, Ultrastructural effects of Clostridium difficile toxin B on smooth muscle cells and fibroblasts. Exp Cell Res148:413-22 1983 |
| PubMed ID: 6628564 |
| |
| Weissman BE, Stanbridge EJ, Complexity of control of tumorigenic expression in intraspecies hybrids of human SV40-transformed fibroblasts and normal human fibroblast cell lines. Cytogenet Cell Genet35:263-8 1983 |
| PubMed ID: 6311488 |
| |
| Wilson VL, Jones PA, DNA methylation decreases in aging but not in immortal cells. Science220:1055-7 1983 |
| PubMed ID: 6844925 |
| |
| Anderson PJ, Actin and tubulin in normal and cystic fibrosis fibroblasts. Biochem Biophys Res Commun108:182-5 1982 |
| PubMed ID: 7150280 |
| |
| Ballard FJ, Nield MK, Francis GL, Dahlenburg GW, Wallace JC, The relationship between the insulin content and inhibitory effects of bovine colostrum on protein breakdown in cultured cells. J Cell Physiol110(3):249-54 1982 |
| PubMed ID: 7045139 |
| |
| Bannai S, Ishii T, Transport of cystine and cysteine and cell growth in cultured human diploid fibroblasts: effect of glutamate and homocysteate. J Cell Physiol112:265-72 1982 |
| PubMed ID: 6126484 |
| |
| Becker D, Lane MA, Cooper GM, Identification of an antigen associated with transforming genes of human and mouse mammary carcinomas. Proc Natl Acad Sci U S A79:3315-9 1982 |
| PubMed ID: 6285346 |
| |
| Carnicero HH, Englard S, Seifter S, Carnitine uptake and fatty acid utilization by diploid cells aging in culture. Arch Biochem Biophys215:78-88 1982 |
| PubMed ID: 7092234 |
| |
| Duthu GS, Braunschweiger KI, Pereira-Smith OM, Norwood TH, Smith JR, A long-lived human diploid fibroblast line for cellular aging studies: applications in cell hybridization. Mech Ageing Dev20:243-52 1982 |
| PubMed ID: 7162221 |
| |
| Fong D, Poole B, The effect of canavanine on protein synthesis and protein degradation in IMR-90 fibroblasts. Biochim Biophys Acta696:193-200 1982 |
| PubMed ID: 7059609 |
| |
| Gallop PM, Paz MA, Henson E, Boradeption: a new procedure for transferring water-insoluble agents across cell membranes. Science217:166-9 1982 |
| PubMed ID: 6178158 |
| |
| Hasegawa N, Hanaoka F, Hori T, Yamada M, Reevaluation of DNA chain elongation rate in human diploid fibroblasts. Exp Cell Res140:443-7 1982 |
| PubMed ID: 7117404 |
| |
| Lamon KD, Chiger JL, Kaji H, Effects of hydrocortisone and aspirin on protein synthesis and post-translational protein modification in cultured cells Biochem Pharmacol31(11):2047-52 1982 |
| PubMed ID: 7115424 |
| |
| Lubin M, Cahn F, Coutermarsh BA, Amiloride, protein synthesis, and activation of quiescent cells. J Cell Physiol113:247-51 1982 |
| PubMed ID: 6294122 |
| |
| Namba M, Fukushima F, Kimoto T, Effects of feeder layers made of human, mouse, hamster, and rat cells on the cloning efficiency of transformed human cells. In Vitro18:469-75 1982 |
| PubMed ID: 6749654 |
| |
| Smerdon MJ, Watkins JF, Lieberman MW, Effect of histone H1 removal on the distribution of ultraviolet-induced deoxyribonucleic acid repair synthesis within chromatin. Biochemistry21:3879-85 1982 |
| PubMed ID: 7138811 |
| |
| Stanbridge EJ, Der CJ, Doersen CJ, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE, Human cell hybrids: analysis of transformation and tumorigenicity. Science215:252-9 1982 |
| PubMed ID: 7053574 |
| |
| Stanbridge EJ, Rosen SW, Sussman HH, Expression of the alpha subunit of human chorionic gonadotropin is specifically correlated with tumorigenic expression in human cell hybrids. Proc Natl Acad Sci U S A79:6242-5 1982 |
| PubMed ID: 6959112 |
| |
| Starling JJ, Sieg SM, Beckett ML, Schellhammer PF, Ladaga LE, Wright GL Jr, Monoclonal antibodies to human prostate and bladder tumor-associated antigens. Cancer Res42:3084-9 1982 |
| PubMed ID: 7046915 |
| |
| Sterling KM Jr, DiPetrillo TA, Kotch JP, Cutroneo KR, Bleomycin-induced increase of collagen turnover in IMR-90 fibroblasts: an in vitro model of connective tissue restructuring during lung fibrosis. Cancer Res42:3502-6 1982 |
| PubMed ID: 6179601 |
| |
| Torrelio BM, Paz MA, Gallop PM, Modulation of purine synthesis and phosphoribosylpyrophosphate content in human fibroblasts at different population doublings. Mech Ageing Dev19:147-58 1982 |
| PubMed ID: 6180262 |
| |
| Ware JL, Paulson DF, Parks SF, Webb KS, Production of monoclonal antibody alpha Pro3 recognizing a human prostatic carcinoma antigen. Cancer Res42:1215-22 1982 |
| PubMed ID: 6174221 |
| |
| Wilson GN, Szura LL, Rushford C, Jackson D, Erickson J, Structure and variation of human ribosomal DNA: the external transcribed spacer and adjacent regions. Am J Hum Genet34:32-49 1982 |
| PubMed ID: 6282117 |
| |
| Absher M, Ryan US, Comparison of pulmonary endothelial cell and fibroblast proliferation using time-lapse cinematographic analysis. Tissue Cell13:645-50 1981 |
| PubMed ID: 7330850 |
| |
| Absher M, Sylwester D, Effects of silica on human lung fibroblasts: survival data analysis of time-lapse cinematography data. Environ Res26:438-52 1981 |
| PubMed ID: 6274632 |
| |
| Bourgeois CA, Raynaud N, Diatloff-Zito C, Macieira-Coehlo A, Effect of low dose rate ionizing radiation on the division potential of cells in vitro. VIII. Cytogenetic analysis of human fibroblasts. Mech Ageing Dev17:225-35 1981 |
| PubMed ID: 7321598 |
| |
| Bradley MO, Taylor VI, DNA double-strand breaks induced in normal human cells during the repair of ultraviolet light damage. Proc Natl Acad Sci U S A78:3619-23 1981 |
| PubMed ID: 6267601 |
| |
| Carnicero HH, Adamany AM, Englard S, Collagen glucosyl- and galactosyltransferases of cultured human fetal lung fibroblasts. Arch Biochem Biophys210:678-90 1981 |
| PubMed ID: 6458240 |
| |
| Der CJ, Stanbridge EJ, A tumor-specific membrane phosphoprotein marker in human cell hybrids. Cell26:429-38 1981 |
| PubMed ID: 7326746 |
| |
| Didinsky JB, Rheinwald JG, Failure of hydrocortisone or growth factors to influence the senescence of fibroblasts in a new culture system for assessing replicative lifespan. J Cell Physiol109:171-9 1981 |
| PubMed ID: 6460039 |
| |
| Erickson LC, Zwelling LA, Ducore JM, Sharkey NA, Kohn KW, Differential cytotoxicity and DNA cross-linking in normal and transformed human fibroblasts treated with cis- diamminedichloroplatinum(II). Cancer Res41:2791-4 1981 |
| PubMed ID: 7195771 |
| |
| Fox N, Fernandez C, Studzinski GP, Visualization of nucleolar substructure in cultured human fibroblasts by magnesium-activated adenosine triphosphatase reaction. J Histochem Cytochem29:1115-20 1981 |
| PubMed ID: 6117591 |
| |
| Gonnerman WA, Ferrera R, Franzblau C, Measurement of medium lysyl oxidase activity in aorta smooth muscle cells. Effects of multiple medium changes and inhibition of protein synthesis. Biochemistry20:3864-7 1981 |
| PubMed ID: 6115672 |
| |
| Hara H, Lamon KD, Kaji H, Effect of temperature on normal and SV40-transformed human fibroblasts. Biochim Biophys Acta673(1):37-45 1981 |
| PubMed ID: 6258653 |
| |
| Hennis HL 3d, Braid HL, Vincent RA Jr, Unscheduled DNA synthesis in cells of different shape in fibroblast cultures from donors of various ages. Mech Ageing Dev16:355-61 1981 |
| PubMed ID: 7300457 |
| |
| Imai K, Galloway DR, Ferrone S, Serological and immunochemical analysis of the specificity of xenoantiserum 8986 elicited with hybrids between human melanoma cells and murine fibroblasts. Cancer Res41:1028-33 1981 |
| PubMed ID: 6161692 |
| |
| James L, Veomett GE, Decreased longevity of human diploid cells after incorporation of latex spheres within their cytoplasm. Exp Cell Res132:468-73 1981 |
| PubMed ID: 7215456 |
| |
| Kelley, Correlation between altered qualitative patterns of cellular protein and cytoskeletal assembly during spreading of progressively subcultivated human embryo fibroblasts (IMR 90). J Cell Biol91:39A (1981):468-73 1981 |
| PubMed ID: 7215456 |
| |
| Kelley J, Trombley L, Kovacs EJ, Davis GS, Absher M, Pulmonary macrophages alter the collagen phenotype of lung fibroblasts. J Cell Physiol109:353-61 1981 |
| PubMed ID: 7298734 |
| |
| Lane MA, Sainten A, Cooper GM, Activation of related transforming genes in mouse and human mammary carcinomas. Proc Natl Acad Sci U S A78:5185-9 1981 |
| PubMed ID: 6272293 |
| |
| Laurent G, Erickson LC, Sharkey NA, Kohn KW, DNA cross-linking and cytotoxicity induced by cis- diamminedichloroplatinum(II) in human normal and tumor cell lines. Cancer Res41:3347-51 1981 |
| PubMed ID: 7196283 |
| |
| Lechner JF, Haugen A, Autrup H, McClendon IA, Trump BF, Harris CC, Clonal growth of epithelial cells from normal adult human bronchus. Cancer Res41:2294-304 1981 |
| PubMed ID: 7016311 |
| |
| McCurry LS, Jacobson MK, Poly(ADP-ribose) synthesis following DNA damage in cells heterozygous or homozygous for the xeroderma pigmentosum genotype. J Biol Chem256:551-3 1981 |
| PubMed ID: 7451457 |
| |
| Morgan AC Jr, Galloway DR, Jensen FC, Giovanella BC, Reisfeld RA, Immunochemical delineation of an oncofetal antigen on normal and simian virus 40-transformed human fetal melanocytes. Proc Natl Acad Sci U S A78:3834-8 1981 |
| PubMed ID: 6267607 |
| |
| Neff NT, Bourret L, Miao P, Dice JF, Degradation of proteins microinjected into IMR-90 human diploid fibroblasts. J Cell Biol91:184-94 1981 |
| PubMed ID: 7028761 |
| |
| Nohga K, Reddy R, Busch H, Comparison of RNase T1 fingerprints of U1, U2, and U3 small nuclear RNA's of HeLa cells, human normal fibroblasts, and Novikoff hepatoma cells. Cancer Res41:2215-20 1981 |
| PubMed ID: 6165460 |
| |
| Ochs DC, McConkey EH, Guard NL, Vimentin-derived proteins: differences between normal human fibroblasts and transformed human cells. Exp Cell Res135:355-62 1981 |
| PubMed ID: 6273192 |
| |
| Ohno T, Growth promotion by preventing G0-arrest does not enhance the replicative life span of human diploid fibroblasts. Mech Ageing Dev15:379-83 1981 |
| PubMed ID: 7242159 |
| |
| Paz MA, Torrelio M, Gallop PM, X-linked processes in serially passaged "aging" human diploid cells. J Gerontol36:142-51 1981 |
| PubMed ID: 7204894 |
| |
| Pool, Rate measurements of retirement from the cell cycle by human fibroblasts in vitro. J Cell Biol91:11a (1981):142-51 1981 |
| PubMed ID: 7204894 |
| |
| Pool TB, Heitman TO, Buck MA, Changes in nuclear shape and mitochondrial structure do not accompany the loss of division potential in human fibroblasts in vitro. Am J Anat162:369-82 1981 |
| PubMed ID: 7325128 |
| |
| Sarber R, Hull B, Merrill C, Soranno T, Bell E, Regulation of proliferation of fibroblasts of low and high population doubling levels grown in collagen lattices. Mech Ageing Dev17:107-17 1981 |
| PubMed ID: 7311621 |
| |
| Stein GH, Yanishevsky RM, Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons. Proc Natl Acad Sci U S A78:3025-9 1981 |
| PubMed ID: 6265932 |
| |
| Taylor L, Schneider E, Smith J, Polgar P, Prostaglandin production and cellular aging. Mech Ageing Dev16:311-7 1981 |
| PubMed ID: 6946268 |
| |
| Trombley L, Absher M, Kelley J, Lung cell population density determines the ratio of type III to type I collagens. Am Rev Respir Dis123:694-6 1981 |
| PubMed ID: 7271072 |
| |
| Vogel KG, Kelley RO, Stewart C, Loss of organized fibronectin matrix from the surface of aging diploid fibroblasts (IMR-90). Mech Ageing Dev16:295-302 1981 |
| PubMed ID: 7029165 |
| |
| Vogel KG, Kendall VF, Sapien RE, Glycosaminoglycan synthesis and composition in human fibroblasts during in vitro cellular aging (IMR-90). J Cell Physiol107:271-81 1981 |
| PubMed ID: 7251685 |
| |
| Vogel KG, Peterson DW, Extracellular, surface, and intracellular proteoglycans produced by human embryo lung fibroblasts in culture (IMR-90). J Biol Chem256:13235-42 1981 |
| PubMed ID: 7309761 |
| |
| Wright WE, Recovery of heterokaryons at high cell densities following isolation using irreversible biochemical inhibitors. Somatic Cell Genet7:769-75 1981 |
| PubMed ID: 7323951 |
| |
| Wu BC, Spohn WH, Busch H, Comparison of nuclear proteins of several human tumors and normal cells by two-dimensional gel electrophoresis. Cancer Res41:336-42 1981 |
| PubMed ID: 7448773 |
| |
| Wu RS, Bonner WM, Separation of basal histone synthesis from S-phase histone synthesis in dividing cells. Cell27:321-30 1981 |
| PubMed ID: 7199388 |
| |
| Absher M, Mortara M, Effect of silica on the proliferative behavior of human lung fibroblasts. In Vitro16:371-6 1980 |
| PubMed ID: 6248451 |
| |
| Ballard FJ, Wong SS, Knowles SE, Partridge NC, Martin TJ, Wood CM, Gunn JM, Insulin inhibition of protein degradation in cell monolayers. J Cell Physiol105:335-46 1980 |
| PubMed ID: 7007398 |
| |
| Bannai S, Ishii T, Formation of sulfhydryl groups in the culture medium by human diploid fibroblasts. J Cell Physiol104:215-23 1980 |
| PubMed ID: 7410490 |
| |
| Bannai S, Kitamura E, Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture. J Biol Chem255:2372-6 1980 |
| PubMed ID: 7358676 |
| |
| Bladon, The change in the proportions of the two major isozyme forms of hexosaminidase in relation to the PDL of various human fibroblasts in culture. J Cell Biol87:286A (1980):2372-6 1980 |
| PubMed ID: 7358676 |
| |
| Brown WT, Ford JP, Gershey EL, Variation of DNA repair capacity in progenia cells unrelated to growth conditions. Biochem Biophys Res Commun97:347-53 1980 |
| PubMed ID: 7458939 |
| |
| Castor, Heterogeneity of mitogenic response within cultures of human diploid fibroblasts. J Cell Biol87:4A (1980):347-53 1980 |
| PubMed ID: 7458939 |
| |
| Civerchia-Perez L, Faris B, LaPointe G, Beldekas J, Leibowitz H, Franzblau C, Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth. Proc Natl Acad Sci U S A77:2064-8 1980 |
| PubMed ID: 6929539 |
| |
| Day RS 3d, Ziolkowski CH, Scudiero DA, Meyer SA, Lubiniecki AS, Girardi AJ, Galloway SM, Bynum GD, Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains. Nature288:724-7 1980 |
| PubMed ID: 6256643 |
| |
| Hann HW, Levy HM, Evans AE, Serum ferritin as a guide to therapy in neuroblastoma. Cancer Res40:1411-3 1980 |
| PubMed ID: 6245792 |
| |
| Imai K, Ferrone S, Indirect rosette microassay to characterize human melanoma-associated antigens recognized by operationally specific xenoantisera. Cancer Res40:2252-6 1980 |
| PubMed ID: 6966965 |
| |
| Kelley, Analysis of heterogeneity in subpopulations of aging IMR90 fibroblasts following fluorescence activated cell sorting . J Cell Biol87:24A (1980):2252-6 1980 |
| PubMed ID: 6966965 |
| |
| Lubin, Growth rate of human diploid cells is sensitive to small decreases in intracellular potassium. Eur J Cell Biol22:486 (1980):2252-6 1980 |
| PubMed ID: 6966965 |
| |
| Ochs, Deficiency of vimentin-associated proteins in HeLa cells and in a virally-transformed fibroblast line. J Cell Biol87:178A (1980):2252-6 1980 |
| PubMed ID: 6966965 |
| |
| Parshad R, Taylor WG, Sanford KK, Camalier RF, Gantt R, Tarone RE, Fluorescent light-induced chromosome damage in human IMR-90 fibroblasts. Role of hydrogen peroxide and related free radicals. Mutat Res73:115-24 1980 |
| PubMed ID: 6789192 |
| |
| Polgar P, Douglas WH, Terracio L, Taylor L, Release of arachidonic acid and its conversion to prostaglandins in various diploid cell types in culture. Adv Prostaglandin Thromboxane Res6:225-9 1980 |
| PubMed ID: 7386262 |
| |
| Polgar P, Taylor L, Alterations in prostaglandin synthesis during senescence of human lung fibroblasts. Mech Ageing Dev12:305-10 1980 |
| PubMed ID: 6993800 |
| |
| Polgar P, Taylor L, Stimulation of prostaglandin synthesis by ascorbic acid via hydrogen peroxide formation. Prostaglandins19:693-700 1980 |
| PubMed ID: 7422888 |
| |
| Roblin R, Young PL, Dexamethasone regulation of plasminogen activator in embryonic and tumor-derived human cells. Cancer Res40:2706-13 1980 |
| PubMed ID: 6771003 |
| |
| Schneider EL, Bickings CK, Aging and sister chromatid exchange. VI. The effect of in vitro passage on spontaneous SCE frequencies in human fetal lung fibroblast cultures. Cytogenet Cell Genet26:61-4 1980 |
| PubMed ID: 7371433 |
| |
| Smerdon MJ, Lieberman MW, Distribution within chromatin of deoxyribonucleic acid repair synthesis occurring at different times after ultraviolet radiation. Biochemistry19:2992-3000 1980 |
| PubMed ID: 7397113 |
| |
| Studzinski GP, Albanese EA, Scatina J, Trocola-Simchera M, Fibroblasts transformed by an oncogenic virus show decreased uptake of puromycin aminonucleoside. Biochem Biophys Res Commun95:1446-51 1980 |
| PubMed ID: 6251841 |
| |
| Sweet F, Kao MS, Lee SC, Hagar WL, Sweet WE, Ozone selectively inhibits growth of human cancer cells. Science209:931-3 1980 |
| PubMed ID: 7403859 |
| |
| Thanassi NM, Rokowski RJ, Sheehy J, Hart B, Absher M, Cutroneo KR, Non-selective decrease of collagen synthesis by cultured fetal lung fibroblasts after non-lethal doses of ethanol. Biochem Pharmacol29:2417-24 1980 |
| PubMed ID: 6158953 |
| |
| Vogel KG, Kendall VF, Cell-surface glycosaminoglycans: turnover in cultured human embryo fibroblasts (IMR-90). J Cell Physiol103:475-87 1980 |
| PubMed ID: 6772652 |
| |
| Weissman B, Stanbridge EJ, Characterization of ouabain resistant, hypoxanthine phosphoribosyl transferase deficient human cells and their usefulness as a general method for the production of human cell hybrids. Cytogenet Cell Genet28:227-39 1980 |
| PubMed ID: 6450667 |
| |
| Anderson PJ, The structure and amount of actin in IMR-90 fibroblasts. Biochem J179:425-30 1979 |
| PubMed ID: 486091 |
| |
| Brown, Two-dimensional analysis of radiolabeled proteins in cultured Huntington's Disease fibroblasts. Adv Neurol23:361 (1979):425-30 1979 |
| PubMed ID: 486091 |
| |
| Chan GL, Little JB, Resistance of plateau-phase human normal and xeroderma pigmentosum fibroblasts to the cytotoxic effect of ultraviolet light. Mutat Res63:401-12 1979 |
| PubMed ID: 522880 |
| |
| Cholon, Differential effect of aminonucleoside on the growth control points in normal versus transformed cells. Fed Proc38:918 (1979):401-12 1979 |
| PubMed ID: 522880 |
| |
| Cholon JJ, Knopf RG, Pine RM, Inhibition of cellular transition from G1-resting to G1-prereplicative phase by aminonucleoside of puromycin. In Vitro15:736-42 1979 |
| PubMed ID: 231571 |
| |
| Houghton BA, Stidworthy GH, A growth history comparison of the human diploid cells WI-38 and IMR- 90: proliferative capacity and cell sizing analysis. In Vitro15:697-702 1979 |
| PubMed ID: 535915 |
| |
| Kennett RH, Gilbert F, Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain. Science203:1120-1 1979 |
| PubMed ID: 424740 |
| |
| McConkey EH, Taylor BJ, Phan D, Human heterozygosity: a new estimate. Proc Natl Acad Sci U S A76:6500-4 1979 |
| PubMed ID: 293737 |
| |
| Ohno T, Strict relationship between dialyzed serum concentration and cellular life span in vitro. Mech Ageing Dev11:179-83 1979 |
| PubMed ID: 513853 |
| |
| Polgar P, Taylor L, Downing D, Unsaturated fatty acid effect on cyclic AMP levels in human embryo lung fibroblasts. Prostaglandins18:43-52 1979 |
| PubMed ID: 230538 |
| |
| Smerdon MJ, Kastan MB, Lieberman MW, Distribution of repair-incorporated nucleotides and nucleosome rearrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts. Biochemistry18:3732-9 1979 |
| PubMed ID: 476082 |
| |
| Stein GH, Yanishevsky RM, Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells. Exp Cell Res120:155-65 1979 |
| PubMed ID: 436949 |
| |
| Sun AS, Alvarez LJ, Reinach PS, Rubin E, 5'-Nucleotidase levels in normal and virus-transformed cells: implications for cellular aging in vitro. Lab Invest41:1-4 1979 |
| PubMed ID: 449279 |
| |
| Vogel KG, Dolde J, Cell-surface glycosaminoglycans are not released from human diploid fibroblasts by non-enzymatic methods. Biochim Biophys Acta552:194-200 1979 |
| PubMed ID: 435494 |
| |
| Friedman HM, Koropchak C, Comparison of WI-38, MRC-5, and IMR-90 cell strains for isolation of viruses from clinical specimens. J Clin Microbiol7:368-71 1978 |
| PubMed ID: 211143 |
| |
| Polgar P, Taylor L, Brown L, Plasma membrane associated metabolic parameters and the aging of human diploid fibroblasts. Mech Ageing Dev7:151-61 1978 |
| PubMed ID: 202816 |
| |
| Wilson GN, Hollar BA, Waterson JR, Schmickel RD, Molecular analysis of cloned human 18S ribosomal DNA segments. Proc Natl Acad Sci U S A75:5367-71 1978 |
| PubMed ID: 364477 |
| |
| Yatscoff RW, Goldstein S, Freeman KB, Conservation of genes coding for proteins synthesized in human mitochondria. Somatic Cell Genet4:633-45 1978 |
| PubMed ID: 741350 |
| |
| Cholon, G0 to G1 transition in human embryonic fibroblasts. J Cell Biol75:15A (1977):633-45 1977 |
| PubMed ID: 741350 |
| |
| Nichols WW, Murphy DG, Cristofalo VJ, Toji LH, Greene AE, Dwight SA, Characterization of a new human diploid cell strain, IMR-90. Science196:60-3 1977 |
| PubMed ID: 841339 |
| PDL at Senescence |
62 |
| Cumulative PDL at Freeze |
19 |
| Passage Frozen |
5 |
| Split Ratio |
1:5 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Percent O2 |
AMBIENT |
| Medium |
Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not inactivated |
| Substrate |
None specified |
| Subcultivation Method |
trypsin-EDTA |
| Supplement |
- |
|