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AG25367 iPSC from Fibroblast

Description:

ALZHEIMER DISEASE, FAMILIAL, TYPE 3
IPSC

Affected:

Yes

Sex:

Female

Age:

31 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Alzheimer's Disease
Protocols Protocol PDF
Biopsy Source Skin
Cell Type Stem cell
Cell Subtype Induced pluripotent stem cell
Transformant Reprogrammed (Sendai)
Sample Source iPSC from Fibroblast
Race White
Ethnicity CANADIAN
Family Member 57
Family History Y
ISCN 46,XX[24].arr(1-22,X)x2
Species Homo sapiens
Common Name Human
Remarks The donor, now deceased, was affected with Alzheimer's disease. Onset of the disease occured at age 45. This diagnosis was updated by the submitter on 3/2009. The skin biopsy was taken ante-mortem from the forearm. Same subject as AG07767 (lymph) and AG07768 (fibroblast). Researchers purchasing hiPSCs from the NIA Repository are responsible for any limited use label licenses (LULLs) applicable to the cell line purchased. The applicable LULL to this line is Sendai-CytoTune.

Characterizations

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Passage Frozen 16
 
Induced Pluripotent Stem Cell The frozen cell line submitted to the Repository was recovered and expanded. The expanded line was evaluated for viability surface antigen expression and alkaline phosphatase activity. Pluripotency was assessed via embryoid body (EB) formation and PluriTest. Steady-state mRNA expression patterns of undifferentiated iPSC and EBs were determined via real-time PCR. Characterization data are included in the Certificate of Analysis.
 

Phenotypic Data

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Remarks The donor, now deceased, was affected with Alzheimer's disease. Onset of the disease occured at age 45. This diagnosis was updated by the submitter on 3/2009. The skin biopsy was taken ante-mortem from the forearm. Same subject as AG07767 (lymph) and AG07768 (fibroblast). Researchers purchasing hiPSCs from the NIA Repository are responsible for any limited use label licenses (LULLs) applicable to the cell line purchased. The applicable LULL to this line is Sendai-CytoTune.

Publications

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Lavekar SS, Harkin J, Hernandez M, Gomes C, Patil S, Huang KC, Puntambekar SS, Lamb BT, Meyer JS, Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease Scientific reports13:13827 2023
PubMed ID: 37620502
 
Shen WB, Logue J, Yang P, Baracco L, Elahi M, Reece EA, Wang B, Li L, Blanchard TG, Han Z, Frieman MB, Rissman RA, Yang P, SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology bioRxiv : the preprint server for biology13:13827 2022
PubMed ID: 35132414

External Links

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NCBI GTR 607822 ALZHEIMER DISEASE 3; AD
OMIM 607822 ALZHEIMER DISEASE 3; AD
Omim Description ALZHEIMER DISEASE, FAMILIAL, TYPE 3; AD3

Culture Protocols

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Passage Frozen 16
Split Ratio 6
Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium HES/Human ES Cell Medium
Serum 20% Knock-out Serum Replacement
Substrate Gelatin + Feeder Layer
Supplement Basic Fibroblast Growth Factor 10ng/ml
Pricing
Commercial:
$1,131.00USD
Academic &
Non-profit:
$823.00USD
NIA Grantees:
$412.00USD
Add to Cart
How to Order
  • Ordering Instructions
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  • NG07768 - DNA
  • AG07768 - Fibroblast
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