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AG11415 Fibroblast from Skin, Arm

Description:

ALZHEIMER DISEASE; AD

Affected:

Yes

Sex:

Male

Age:

55 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Alzheimer's Disease
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Sample Source Fibroblast from Skin, Arm
Race White
Ethnicity FRENCH CANADIAN
Family Member 1
Relation to Proband proband
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks Donor has a history of progressive dementia and memory loss with onset at age 48. Donor's deceased father and a sister were affected. Biopsy was taken ante-mortem from the upper arm. Culture was initiated on 11/19/90 using explants of minced skin tissue. The cell morphology is fibroblastlike. The karyotype is 46,XY with 4% of the cells examined showing random chromosome loss and 12% showing chromosomal rearrangements; normal diploid male. Culture was frozen at passage 4 and the PDL is unknown. A lymphoblast culture from same donor is AG11366. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

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Passage Frozen 10
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis
 

Phenotypic Data

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Remarks Donor has a history of progressive dementia and memory loss with onset at age 48. Donor's deceased father and a sister were affected. Biopsy was taken ante-mortem from the upper arm. Culture was initiated on 11/19/90 using explants of minced skin tissue. The cell morphology is fibroblastlike. The karyotype is 46,XY with 4% of the cells examined showing random chromosome loss and 12% showing chromosomal rearrangements; normal diploid male. Culture was frozen at passage 4 and the PDL is unknown. A lymphoblast culture from same donor is AG11366. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Publications

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Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, et al, Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science258:668-71 1992
PubMed ID: 1411576

External Links

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dbSNP dbSNP ID: 21006
NCBI GTR 104300 ALZHEIMER DISEASE; AD
OMIM 104300 ALZHEIMER DISEASE; AD
Omim Description ALZHEIMER DISEASE, FAMILIAL; FAD
  ALZHEIMER DISEASE; AD
  PRESENILE AND SENILE DEMENTIA

Culture Protocols

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Passage Frozen 10
Split Ratio 1:2
Temperature 37 C
Percent CO2 5%
Medium Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not inactivated
Substrate None specified
Subcultivation Method trypsin-EDTA
Supplement -
Pricing
Commercial:
$257.00USD
Academic &
Non-profit:
$103.00USD
NIA Grantees:
$47.00USD
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How to Order
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