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AG08517 Fibroblast from Skin, Arm

Description:

ALZHEIMER DISEASE; AD

Affected:

No

Sex:

Female

Age:

66 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection German Alzheimer Disease
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Sample Source Fibroblast from Skin, Arm
Race White
Ethnicity GERMAN
Family Member 16
Relation to Proband V-24
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The donor is an unaffected spouse of an Alzheimer's disease family member. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 11/05/85 using explants of minced skin. The cell morphology is fibroblast-like. Culture was frozen at PDL 4. A lymphoblast culture from same donor is AG08516.

Characterizations

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PDL at Freeze 4
Passage Frozen 2
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase and Glucose-6-Phosphate Dehydrogenase Isoenzyme Electrophoresis
 

Phenotypic Data

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Remarks The donor is an unaffected spouse of an Alzheimer's disease family member. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 11/05/85 using explants of minced skin. The cell morphology is fibroblast-like. Culture was frozen at PDL 4. A lymphoblast culture from same donor is AG08516.

Publications

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Iannuzzi F, Frisardi V, Annunziato L, Matrone C, Might Fibroblasts from Patients with Alzheimer's Disease Reflect the Brain Pathology? A Focus on the Increased Phosphorylation of Amyloid Precursor Protein Tyr Brain sciences11: 2020
PubMed ID: 33466666
 
Gonzalez C, Armijo E, Bravo-Alegria J, Becerra-Calixto A, Mays CE, Soto C, Modeling amyloid beta and tau pathology in human cerebral organoids Molecular psychiatry11: 2017
PubMed ID: 30171212
 
Frommelt P, Schnabel R, Kuhne W, Nee LE, Polinsky RJ, Familial Alzheimer disease: a large, multigeneration German kindred. Alzheimer Dis Assoc Disord5:36-43 1991
PubMed ID: 2025423
 
St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, et al, The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science235:885-90 1987
PubMed ID: 2880399

External Links

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dbSNP dbSNP ID: 20916
NCBI GTR 104300 ALZHEIMER DISEASE; AD
OMIM 104300 ALZHEIMER DISEASE; AD
Omim Description ALZHEIMER DISEASE, FAMILIAL; FAD
  ALZHEIMER DISEASE; AD
  PRESENILE AND SENILE DEMENTIA

Culture Protocols

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Cumulative PDL at Freeze 4
Passage Frozen 2
Split Ratio 1:5
Temperature 37 C
Percent CO2 5%
Medium Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not inactivated
Substrate None specified
Subcultivation Method trypsin-EDTA
Supplement -
Pricing
Commercial:
$257.00USD
Academic &
Non-profit:
$103.00USD
NIA Grantees:
$47.00USD
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