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AG08243 Fibroblast from Skin, Arm

Description:

ALZHEIMER DISEASE; AD

Affected:

Yes

Sex:

Male

Age:

72 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Alzheimer's Disease
Alzheimer Disease With No Family History
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Sample Source Fibroblast from Skin, Arm
Race White
Family Member 1
Relation to Proband proband
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The donor is a clinically affected Alzheimer's disease patient. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 6/11/85 using explants of minced skin. The cell morphology is fibroblastlike. Culture was frozen at PDL 10. The culture is a mosaic with karyotype: 46,XY/47,XY,+mar; 94%/6% with 10% of the cells examined showing random chromosome loss/gain. A lymphoblast culture from same donor is AG08242. The family history is negative for other cases of Alzheimer's disease. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

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PDL at Freeze 4.98
Passage Frozen 4
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis
 

Phenotypic Data

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Remarks The donor is a clinically affected Alzheimer's disease patient. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 6/11/85 using explants of minced skin. The cell morphology is fibroblastlike. Culture was frozen at PDL 10. The culture is a mosaic with karyotype: 46,XY/47,XY,+mar; 94%/6% with 10% of the cells examined showing random chromosome loss/gain. A lymphoblast culture from same donor is AG08242. The family history is negative for other cases of Alzheimer's disease. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Publications

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Hanna R, Flamier A, Barabino A, Bernier G, G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease Nature communications12:1828 2019
PubMed ID: 33758195
 
Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA, REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease Cell reports26:1112-1127.e9 2018
PubMed ID: 30699343
 
Etcheberrigaray E, Gibson GE, Alkon DL, Molecular mechanisms of memory and the pathophysiology of Alzheimer's disease. Ann N Y Acad Sci747:245-55 1994
PubMed ID: 7847674
 
Etcheberrigaray R, Ito E, Kim CS, Alkon DL, Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. Science264:276-9 1994
PubMed ID: 8146663
 
Ito E, Oka K, Etcheberrigaray R, Nelson TJ, McPhie DL, Tofel-Grehl B, Gibson GE, Alkon DL, Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci U S A91:534-8 1994
PubMed ID: 8290560
 
Etcheberrigaray R, Ito E, Oka K, Tofel-Grehl B, Gibson GE, Alkon DL, Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease. Proc Natl Acad Sci U S A90:8209-13 1993
PubMed ID: 8367484

External Links

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dbSNP dbSNP ID: 10168
NCBI GTR 104300 ALZHEIMER DISEASE; AD
OMIM 104300 ALZHEIMER DISEASE; AD
Omim Description ALZHEIMER DISEASE, FAMILIAL; FAD
  ALZHEIMER DISEASE; AD
  PRESENILE AND SENILE DEMENTIA

Culture Protocols

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Cumulative PDL at Freeze 7.98
Passage Frozen 4
Split Ratio 1:2
Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not inactivated
Supplement -
Pricing
Commercial:
$257.00USD
Academic &
Non-profit:
$103.00USD
NIA Grantees:
$47.00USD
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How to Order
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