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AG07714 Fibroblast from Skin, Arm

Description:

GERONTOLOGY RESEARCH CENTER (GRC) CELL CULTURE COLLECTION
BALTIMORE LONGITUDINAL STUDY ON AGING (BLSA)

Affected:

No

Sex:

Female

Age:

56 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links
  • Culture Protocols

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection GRC
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Sample Source Fibroblast from Skin, Arm
Race White
Family Member 3
Relation to Proband spouse
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The biopsy site is the mesial aspect of the mid-upper left arm, taken antemortem. The primary culture was initiated from explants of a 2 mm-punch biopsy. The cell morphology is fibroblast-like. The culture is a mosaic with karyotype: 46,XX/46,XX,1p+,3p-,3q-,10q-,13p+,16q+; 94%/6%. A culture initiated from a biopsy taken 10 years later from this same donor is AG12927. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

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PDL at Freeze 12
 
IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Chromosome Analysis
 

Phenotypic Data

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Remarks The biopsy site is the mesial aspect of the mid-upper left arm, taken antemortem. The primary culture was initiated from explants of a 2 mm-punch biopsy. The cell morphology is fibroblast-like. The culture is a mosaic with karyotype: 46,XX/46,XX,1p+,3p-,3q-,10q-,13p+,16q+; 94%/6%. A culture initiated from a biopsy taken 10 years later from this same donor is AG12927. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Publications

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Park TS, Huo JS, Peters A, Talbot CC, Verma K, Zimmerlin L, Kaplan IM, Zambidis ET, Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors PloS one7:e42838 2012
PubMed ID: 22905176
 
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA, Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations Cell141:1146-58 2008
PubMed ID: 20541250
 
Colige A, Nusgens B, Lapiere CM, Response to epidermal growth factor of skin fibroblasts from donors of varying age is modulated by the extracellular matrix. J Cell Physiol145:450-7 1990
PubMed ID: 1703167

External Links

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dbSNP dbSNP ID: 13756
GEO GEO Accession No: GSM1094007
GEO Accession No: GSM1094008
GEO Accession No: GSM1094009
GEO Accession No: GSM860979
GEO Accession No: GSM860980
GEO Accession No: GSM860981
GEO Accession No: GSM860982
GEO Accession No: GSM860983
GEO Accession No: GSM860984

Culture Protocols

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Cumulative PDL at Freeze 12
Split Ratio 1:2
Temperature 37 C
Medium Eagle's MEM with Hank's BSS, with 26mM Hepes; ambient CO2 with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not inactivated
Substrate None specified
Subcultivation Method trypsin-EDTA
Supplement -
Pricing
Commercial:
$257.00USD
Academic &
Non-profit:
$103.00USD
NIA Grantees:
$47.00USD
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