GM16442

GM16442 LCL from B-Lymphocyte

Description:

TRANSLOCATED CHROMOSOME

Affected:

No Data

Sex:

Male

Age:

No Data

Overview

Repository

NIGMS Human Genetic Cell Repository

Subcollection

Chromosome Abnormalities

Biopsy Source

Peripheral vein

Cell Type

B-Lymphocyte

Tissue Type

Blood

Transformant

Epstein-Barr Virus

Sample Source

LCL from B-Lymphocyte

Family Member

Relation to Proband

son

Confirmation

Karyotypic analysis after cell line submission to CCR

ISCN

46,XY,t(14;18)(14pter>14q21::18q22.1>18qter;18pter>18q22.1::14q21>14qter)mat

Species

Homo sapiens

Common Name

Human

Remarks

JL482; son of mother (GM16440) with affective disorder; too young for diagnostic evaluation

Characterizations

IDENTIFICATION OF SPECIES OF ORIGIN

Species of Origin Confirmed by Nucleoside Phosphorylase,Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis

Cytogenetics

Chromosome 14: DERIVATIVE CHROMOSOME Breakpoint 14q21 t(14;18)14q21

Chromosome 14: TRANSLOCATION Breakpoint 14q21

Chromosome 14: TRANSLOCATION Breakpoint 14q21 t(14;18)14q21

Chromosome 18: DERIVATIVE CHROMOSOME Breakpoint 18q22 t(14;18)18q22

Chromosome 18: TRANSLOCATION Breakpoint 18q22

Chromosome 18: TRANSLOCATION Breakpoint 18q22 t(14;18)18q22

Phenotypic Data

Remarks

JL482; son of mother (GM16440) with affective disorder; too young for diagnostic evaluation

Publications

Overhauser J, Berrettini WH, Rojas K, Affective disorder associated with a balanced translocation involving chromosome 14 and 18. Psychiatr Genet8(2):53-6 1998

PubMed ID: 9686423

External Links

dbSNP

dbSNP ID: 16769

Images

View

karyotype

Culture Protocols

Split Ratio

1:3

Temperature

37 C

Percent CO2

Medium

Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent

Serum

15% fetal bovine serum Not Inactivated

Substrate

None specified

Subcultivation Method

dilution - add fresh medium

Supplement

Pricing

Commercial/For-profit:

$311.00USD

Academic/Non-profit/Government:

$176.00USD