Induced Pluripotent Stem Cells
To facilitate research on differentiated cell types and other biomedical investigations, the NIGMS Repository offers human induced pluripotent stem cell (hiPSC) lines derived from apparently healthy individuals or from individuals affected with heritable diseases. These hiPSCs were created using a variety of reprogramming techniques*.

Some of the available hiPSC lines were derived from externally submitted iPSC lines, where a distribution stock was made. Others were derived from established LCLs or Fibroblast lines available in the catalog. In addition to QC tests (viability, contamination, karyotyping, microarray genotyping, and microsatellite matches with the parent cell culture), extensive pluripotency characterizations are performed on each NIGMS Repository hiPSC line. Pluripotency characterizations include the following assays:

  • Surface antigen expression
  • Embryoid body formation
  • PluriTest gene expression assay
A complete Certificate of Analysis (CofA) that includes images and quantitative test results is available for each hiPSC line. The CofA PDF specifies which pluripotency characterizations were performed on each hiPSC line.

The Protocol PDFs outline the proper steps for successful handling of the hiPSCs. Additional information is also found on the CofA PDF, including necessary media components, substrates, passage methods, and split ratios.

* For commercial purposes, please note that Limited Use Label Licenses (LULLs) may apply.

Apparently Healthy hiPSC Lines
Records Return:  (15) Show

Catalog IDDescriptionParent LineTransformantLULLGenderAgeRaceBiopsy SourceAffected StatusRelated SamplesCertificate of AnalysisProtocol
GM23392APPARENTLY HEALTHY FETAL TISSUEGM06114Reprogrammed (Retroviral) WARFMale20 FWBlackLungNo910CofA PDFProtocol PDF
GM23396APPARENTLY HEALTHY FETAL TISSUEGM06111Reprogrammed (Retroviral) WARFFemale16 FWBlackSkinNo911CofA PDFProtocol PDF
GM23413APPARENTLY HEALTHY FETAL TISSUEGM06112Reprogrammed (Retroviral) WARFFemale16 FWBlackLungNo911CofA PDFProtocol PDF
GM23450APPARENTLY HEALTHY FETAL TISSUEGM06113Reprogrammed (Retroviral) WARFMale20 FWBlackSkinNo910CofA PDFProtocol PDF
GM23716APPARENTLY HEALTHY FETAL TISSUEGM06111Reprogrammed (Episomal)WARFFemale16 FWBlackSkinNo911CofA PDFProtocol PDF
GM23279APPARENTLY HEALTHY INDIVIDUALNot in RepositoryReprogrammed (Retroviral) IP ACADEMIA JAPANFemale36 YRCaucasianSkinNo2997CofA PDFProtocol PDF
GM23280APPARENTLY HEALTHY INDIVIDUALNot in RepositoryReprogrammed (Retroviral) IP ACADEMIA JAPANFemale36 YRCaucasianSkinNo2997CofA PDFProtocol PDF
GM23476APPARENTLY HEALTHY INDIVIDUALGM04506LentivirusWARFFemale20 YRCaucasianSkinNo732CofA PDFProtocol PDF
GM23720APPARENTLY HEALTHY INDIVIDUALGM02254Reprogrammed (Episomal)WARFFemale22 YRCaucasianPeripheral veinNo3045CofA PDFProtocol PDF
GM25256APPARENTLY HEALTHY INDIVIDUALNot in RepositoryReprogrammed (Episomal)IP ACADEMIA JAPANMale30 YRAsianSkinNo3181CofA PDFProtocol PDF
GM25430APPARENTLY HEALTHY INDIVIDUALNot in RepositoryReprogrammed (Retroviral) IP ACADEMIA JAPANMale62 YRCaucasianArmNo3238CofA PDFProtocol PDF
GM23338PERSONAL GENOME PROJECTGM23248Reprogrammed (Retroviral) IP ACADEMIA JAPANMale55 YRCaucasianSkinNo2980CofA PDFProtocol PDF
GM26077PERSONAL GENOME PROJECTGM24143Reprogrammed (Episomal)IP ACADEMIA JAPANFemale74 YRCaucasian Unknown3140CofA PDFProtocol PDF
GM26105PERSONAL GENOME PROJECTGM24385Reprogrammed (Episomal)IP ACADEMIA JAPANMale45 YRCaucasian Unknown3140CofA PDFProtocol PDF
GM26107PERSONAL GENOME PROJECTGM24631Reprogrammed (Episomal)IP ACADEMIA JAPANMale33 YRAsian, Other Unknown3150CofA PDFProtocol PDF

Disease-Specific hiPSC Lines
Records Return:  (39) Show

Catalog IDDiagnosisParent LineTransformantGenderLULLAgeRaceBiopsy SourceAffected StatusGene(s)Mutation(s)Family and Associated SpecimensCertificate of AnalysisProtocol
GM24666ALZHEIMER DISEASE; ADNot in RepositoryReprogrammed (Retroviral) MaleIP ACADEMIA JAPAN83 YRCaucasianSkinYes  3234CofA PDFProtocol PDF
GM24675ALZHEIMER DISEASE; ADNot in RepositoryReprogrammed (Retroviral) FemaleIP ACADEMIA JAPAN60 YR SkinYes  3236CofA PDFProtocol PDF
3406CofA PDFProtocol PDF
GM26650CHOROIDEREMIA; CHMGM25393Reprogrammed (Sendai)MaleSendai-Cyto Tune57 YRCaucasianSkinYesCHM CHMc.189+1G>T
3214CofA PDFProtocol PDF
GM26663CHOROIDEREMIA; CHMGM25383Reprogrammed (Sendai)MaleSendai-Cyto Tune20 YRCaucasianSkinYesCHM CHM CHMARG270TER
3210CofA PDFProtocol PDF
GM24683CYSTIC FIBROSIS; CFGM01014Reprogrammed (Episomal)MaleIP ACADEMIA JAPAN13 YRCaucasian YesCFTR CFTRPHE508DEL
93CofA PDFProtocol PDF
GM23226DIABETES MELLITUS, JUVENILE-ONSET INSULIN-DEPENDENT; IDDMGM02416Reprogrammed (Retroviral) FemaleIP ACADEMIA JAPAN42 YRAmerican IndianSkinYes  383CofA PDFProtocol PDF
GM24559DYSTROPHIA MYOTONICA 1; DM1GM04602Reprogrammed (Episomal)FemaleIP ACADEMIA JAPAN2 YRCaucasianSkinYes  583CofA PDFProtocol PDF
GM26017EPIDERMOLYSIS BULLOSA: DYSTROPHIC, JUNCTIONAL, OR SIMPLEX TYPESGM10269Reprogrammed (Sendai)MaleSendai-Cyto Tune4 YRCaucasian Yes  1186CofA PDFProtocol PDF
GM27327FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1; FSHD1GM16277Reprogrammed (Episomal)FemaleIP ACADEMIA JAPAN77 YR Peripheral veinYes  1939CofA PDFProtocol PDF
GM23404FRIEDREICH ATAXIA 1; FRDAGM03816Reprogrammed (Retroviral) FemaleIP ACADEMIA JAPAN36 YRCaucasianSkinYesFXN FXN(GAA)n EXPANSION
594CofA PDFProtocol PDF
GM23913FRIEDREICH ATAXIA 1; FRDAGM04078Reprogrammed (Retroviral) MaleIP ACADEMIA JAPAN30 YRCaucasianSkinYesFXN FXN(GAA)n EXPANSION
594CofA PDFProtocol PDF
GM23225HUNTINGTON DISEASE; HD GM04281Reprogrammed (Retroviral) FemaleIP ACADEMIA JAPAN20 YRCaucasianSkinYesHD(CAG)n EXPANSION
690CofA PDFProtocol PDF
GM26656HURLER SYNDROMEGM00798Reprogrammed (Sendai)FemaleSendai-Cyto Tune1 YRCaucasianSkinYesIDUA IDUATRP402TER
41CofA PDFProtocol PDF
GM26029KEARNS-SAYRE SYNDROME; KSSGM06225Reprogrammed (Sendai)MaleSendai-Cyto Tune10 YRCaucasianSkinYes  931CofA PDFProtocol PDF
GM26644KRABBE DISEASEGM06806Reprogrammed (Sendai)FemaleSendai-Cyto Tune2 YRCaucasian YesGALC GALC30-KB DEL, IVS10
30-KB DEL, IVS10
962CofA PDFProtocol PDF
72CofA PDFProtocol PDF
GM25305LONG QT SYNDROME 2; LQT2Not in RepositoryReprogrammed (Retroviral) FemaleIP ACADEMIA JAPAN48 YRAsianSkinYesKCNH2ALA422THR
3183CofA PDFProtocol PDF
GM25267LONG QT SYNDROME 3; LQT3Not in RepositoryReprogrammed (Retroviral) FemaleIP ACADEMIA JAPAN18 YRCaucasianSkinYesSCN5AASN406LYS
3184CofA PDFProtocol PDF
GM26025MILLER-DIEKER LISSENCEPHALY SYNDROME; MDLSGM06097Reprogrammed (Sendai)FemaleSendai-Cyto Tune1 YRCaucasianSkinYes  3360CofA PDFProtocol PDF