| Gene | Description | Location | Gene Omim Number | Disease Omim Number |
| SCN5A | SODIUM VOLTAGE-GATED CHANNEL, ALPHA SUBUNIT 5; SCN5A | 3p22.2 | 600163 | 600163 |
| SEPN1 | SELENOPROTEIN N; SELENON | 1p36-p35 | 606210 | 602771 |
| SGSH | N-SULFOGLUCOSAMINE SULFOHYDROLASE; SGSH | 17q25.3 | 605270 | 605270 |
| SH3BP2 | SH3 DOMAIN-BINDING PROTEIN 2; SH3BP2 | 4p16.3 | 602104 | 602104 |
| SH3TC2 | SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT DOMAIN 2; SH3TC2 | 5q32 | 608206 | 608206 |
| SHOX | SHORT STATURE HOMEOBOX; SHOX | Xpter-p22.32 | 312865 | 312865 |
| SLC17A5 | SOLUTE CARRIER FAMILY 17 (ACIDIC SUGAR TRANSPORTER), MEMBER 5; SLC17A5 | 6q14-q15 | 604322 | 604322 |
| SLC25A13 | SOLUTE CARRIER FAMILY 25 (CITRIN), MEMBER 13; SLC25A13 | 7q21.3 | 603859 | 603859 |
| SLC25A4 | SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, ADENINE NUCLEOTIDE TRANSLOCATOR), MEMBER 4; SLC25A4 | 4q35.1 | 103220 | 103220 |
| SLC26A2 | SOLUTE CARRIER FAMILY 26 (SULFATE TRANSPORTER), MEMBER 2; SLC26A2 | 5q32 | 606718 | 606718 |
| SLC2A1 | SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER 1; SLC2A1 | 1p34.2 | 138140 | 138140 |
| SLC3A1 | SOLUTE CARRIER FAMILY 3 (CYSTINE, DIBASIC, AND NEUTRAL AMINO ACID TRANSPORTER), MEMBER 1; SLC3A1 | 2p16.3 | 104614 | 104614 |
| SLC6A19 | SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER), MEMBER 19; SLC6A19 | 5p15 | 608893 | 608893 |
| SLC6A3 | SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE), MEMBER 3; SLC6A3 | 5p15.33 | 126455 | 126455 |
| SLC7A9 | SOLUTE CARRIER FAMILY 7 (CATIONIC AMINO ACID TRANSPORTER, y+ SYSTEM), MEMBER 9 | 19q13.1 | 604144 | 604144 |
| SMAD4 | SMAD FAMILY MEMBER 4; SMAD4 | 18q21.2 | 600993 | 600993 |
| SMC1A | STRUCTURAL MAINTENANCE OF CHROMOSOMES 1A; SMC1A | Xp11.22 | 300040 | 300040 |
| SMN1 | SURVIVAL OF MOTOR NEURON 1; SMN1 | 5q12.2-q13.3 | 600354 | 600354 |
| SMPD1 | SPHINGOMYELIN PHOSPHODIESTERASE 1, ACID LYSOSOMAL; SMPD1 | 11p15.4-p15.1 | 607608 | 607608 |
| SNCA | SYNUCLEIN, ALPHA; SNCA | 4q21 | 163890 | 163890 |
| SNRPN | SMALL NUCLEAR RIBONUCLEOPROTEIN POLYPEPTIDE N; SNRPN | 15q12 | 182279 | 182279 |
| SOD1 | SUPEROXIDE DISMUTASE 1; SOD1 | 21q22.11 | 147450 | 147450 |
| SYNGAP1 | SYNAPTIC RAS-GTPase-ACTIVATING PROTEIN 1; SYNGAP1 | 6p21.32 | 603384 | 603384 |