Specimen Collections

The Coriell Cell Repositories provide essential research biomaterials to the scientific community by establishing, verifying, maintaining, and distributing cell cultures and DNA. These collections, supported by funds from the National Institutes of Health (NIH) and several foundations, are extensively utilized by research scientists around the world.

Many important research successes have been accomplished using Coriell-managed biospecimens. A prime example is also one of the first: A team of scientists headed by Dr. Nancy Wexler went to Venezuela where an isolated village was found with a high incidence of Huntington’s disease. In 1979, cells were brought back to Coriell, cultures established and frozen, and distributed to scientists involved in the search for the Huntington’s gene. Five years later, the gene was localized on chromosome 4. In 1994, the gene itself was isolated. From this significant breakthrough, Dr. Wexler and other researchers continue their Huntington’s disease research to seek improved treatments.

Click here to access the Coriell Biorepository catalog.

Coriell’s significant cell biobank collections include:

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The Human Genetic Cell Repository, sponsored by the National Institute of General Medical Sciences (NIGMS), provides scientists around the world with resources for cell and genetic research. The samples include highly characterized cell lines and high quality DNA. Repository samples represent a variety of disease states, chromosomal abnormalities, apparently healthy individuals, and many distinct human populations.
Link to NIGMS collection

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The National Institute of Neurological Disorders and Stroke (NINDS) is committed to gene discovery, as a strategy for identifying the genetic causes and correlates of nervous system disorders. The NINDS Human Genetics DNA and Cell Line Repository banks samples from subjects with cerebrovascular disease, epilepsy, motor neuron disease, Parkinsonism, and Tourette Syndrome, as well as controls.
Link to NINDS collection

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Sponsored by the National Institute on Aging (NIA), the Aging Cell Repository is a resource facilitating cellular and molecular research studies on the mechanisms of aging and the degenerative processes associated with it. Scientists use the highly-characterized, viable, and contaminant-free cell cultures from this collection for research on such diseases as Alzheimer disease, progeria, Parkinsonism, Werner syndrome, and Cockayne syndrome.
Link to NIA collection

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The National Human Genome Research Institute (NHGRI) Sample Repository for Human Genetic Research offers DNA samples and cell lines from fifteen populations, including the samples used for the International HapMap Project, the HapMap 3 Project and the 1000 Genomes Project (except for the CEPH samples). All of the samples were contributed with consent to broad data release and to their use in many future studies, including for extensive genotyping and sequencing, gene expression and proteomics studies, and all other types of genetic variation research. The samples are high-quality resources for the study of genetic variation in a range of human populations.
Link to NHGRI collection

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The Age-Related Eye Disease Study (AREDS) was designed to learn about macular degeneration and cataract, two leading causes of vision loss in older adults. The study looked at how these two diseases progress and what their causes may be. In addition, the study tested certain vitamins and minerals to find out if they can help to prevent or slow these diseases.
Link to NEI AREDS collection

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HD Community BioRepository (www.chdifoundation.org) supported by CHDI is a secure, centralized repository to store and distribute quality-controlled and reliable research reagents. This repository currently provides access to huntingtin DNAs, polyclonal antibodies (with antigenic peptides), and cell lines. Monoclonal antibodies and hybridomas will be added in the near future.
Link to HD Community BioRepository collection

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The State of New Jersey funded the initiation of a genetic resource to support the study of autism in families where more than one child is affected or where one child is affected and one demonstrates another significant and related developmental disorder. This resource now receives continuing support from the Coriell Institute for Medical Research. An open bank of anonymously collected materials documented by a detailed clinical diagnosis forms the basis of this growing database of information about the disease.
Link to Autism Research Resource collection